PDF(Pubmed)
Abstract：
Curcumin (CCM) is a polyphenol compound extracted from the turmeric rhizome. It has various biological activities, including antibacterial, anti-inflammatory, anti-cancer, and antioxidant. Due to its diverse activities, it is often used by researchers to study the therapeutic effects on various diseases. However, its poor solubility leads to poor bioavailability, and it is necessary to increase the water solubility with the help of carriers to improve the therapeutic effect. Gastrointestinal disease is a major global health problem that continues to affect human health. In this review, we have summarized the possible mechanism and therapeutic effect of CCM in various gastrointestinal diseases, and the improvement in the curative effect of CCM with nanopreparation. Finally, we concluded that there have been many clinical trials of CCM in combination with other drugs for the treatment of gastrointestinal disease, but so far, few have used CCM nanomaterials for treatment. Although in vitro and preclinical experiments have shown that nanopreparations can improve the efficacy of CCM, there are still insufficient studies on the safety of carriers.
摘要：
姜黄素（CCM）是从姜黄根茎中提取的多酚化合物。它具有多种生物活性,包括抗菌，抗炎,抗癌，和抗氧化剂。由于其活动的多样性，研究人员经常使用它来研究对各种疾病的治疗效果。然而,它的溶解性差导致生物利用度差，有必要在载体的帮助下增加水溶性以提高治疗效果。胃肠病是全球范围内持续影响人类健康的重大健康问题。在这次审查中,综述了CCM在多种胃肠道疾病中的可能作用机制和治疗效果,纳米修复剂对CCM疗效的改善。最后,我们的结论是，已经有许多CCM与其他药物联合治疗胃肠道疾病的临床试验，但到目前为止,很少有人使用CCM纳米材料进行治疗。尽管体外和临床前实验表明，纳米分离可以提高CCM的疗效，关于承运人安全的研究仍然不足。
