目标:建立院前症状网络,探索核心,桥和前哨症状,对肝硬化失代偿期患者院前症状群进行识别,分析影响因素与症状群的关系。
方法:采用加强流行病学检查表中观察性研究报告的横断面研究设计。
方法:人口统计学,生理,我们收集了2021年10月至2023年3月在中国的292例失代偿期肝硬化患者的心理和社会学特征以及院前症状.频率,百分比,means,标准偏差,独立样本t检验,单向方差分析,探索性因素分析,采用多元逐步回归分析和网络分析进行数据分析.
结果:\“我看起来不像自己\”和瘙痒是核心和桥症状,而腹胀和缺乏能量是失代偿期肝硬化患者的前哨症状。家庭月收入,焦虑,抑郁症,社会支持和疾病持续时间影响神经心理症状群,担忧是最强的预测症状。肝硬化特异性症状群的影响因素包括Child-Pugh级,家庭月收入,疾病持续时间,焦虑和抑郁,瘙痒是最强的预测症状。家庭月收入,病程和抑郁是胃肠道症状群的影响因素,食欲不振是最强的预测症状。
结论:神经心理学,在失代偿期肝硬化患者中形成了肝硬化特异性和胃肠道症状群。通过网络分析,症状之间的直接联系,揭示了症状群及其影响因素,从而为临床医生提供了有效管理患者院前症状的基础。
结论:失代偿期肝硬化患者通常有多种症状,而院前症状的管理往往不理想。这项研究确定了神经心理学,肝硬化特异性,胃肠道症状群和公认的核心,这些患者的桥和前哨症状。它还揭示了每个集群中最突出的症状。这提供了对症状层次结构的洞察,改善失代偿期肝硬化的症状管理。
■没有患者或公众参与。
OBJECTIVE: To generate pre-hospital symptom networks, explore core, bridge and sentinel symptoms, identify pre-hospital symptom clusters and analyse relationship between influencing factors and symptom clusters in decompensated cirrhosis patients.
METHODS: A cross-sectional study design using the Strengthening the Reporting of Observational Studies in Epidemiology checklist.
METHODS: Demographical, physiological, psychological and sociological characteristics and the pre-hospital symptoms of 292 decompensated cirrhotic patients were collected from October 2021 to March 2023 in
China. Frequencies, percentages, means, standard deviations, independent samples t-tests, one-way analysis of variance, exploratory factor analysis, multiple stepwise regression analysis and network analysis were used for data analysis.
RESULTS: \'I don\'t look like myself\' and itching were core and bridge symptoms, while bloating and lack of energy were sentinel symptoms in decompensated cirrhotic patients. Monthly family income, anxiety, depression, social support and disease duration influenced the neuropsychological symptom cluster, with worrying as the strongest predictor symptom. Influential factors for cirrhosis-specific symptom cluster included Child-Pugh class, monthly family income, disease duration, anxiety and depression, with itching being the strongest predictor symptom. Monthly family income, disease duration and depression were influential factors for gastrointestinal symptom cluster, with loss of appetite as the strongest predictor symptom.
CONCLUSIONS: Neuropsychological, cirrhosis-specific and gastrointestinal symptom clusters were formed in decompensated cirrhotic patients. Through network analysis, direct connections between symptoms, symptom clusters and their influencing factors were revealed, thereby offering clinicians a foundation for effectively managing patients\' pre-hospital symptoms.
CONCLUSIONS: Decompensated cirrhosis patients commonly have multiple symptoms, while the management of pre-hospital symptoms is often suboptimal. This study identified neuropsychological, cirrhosis-specific, gastrointestinal symptom clusters and recognized core, bridge and sentinel symptoms in these patients. It also revealed the most prominent symptoms within each cluster. This provides insight into the hierarchy of symptoms, improving symptom management in decompensated cirrhosis.
UNASSIGNED: There was no patient or public involvement.