背景:这里,我们小组设计了一种新颖的技术,称为球囊压迫辅助内窥镜注射硬化疗法(BC-EIS),用于提高根除食管静脉曲张(EV)的效率。本研究旨在比较BC-EIS和内镜静脉曲张结扎术(EVL)在EV治疗中的根除率和疗效。
方法:95例食管静脉曲张破裂出血(EVB)患者被随机分配接受BC-EIS或单独结扎。1个月后进行额外的治疗,然后每隔3个月进行一次,直到静脉曲张根除为止。在没有复发的情况下或在有任何复发性出血的情况下立即进行6个月的内窥镜随访检查。
结果:在bc-EIS组中,每个疗程的平均物理注射点数为2.89±0.79,每个疗程的聚桂醇平均用量为17.74±7.09ml。每个疗程的平均波段为6.13±0.86。BC-EIS一至三轮根除率明显高于EVL组(89.36%,97.87%,和100%vs.37.5%,43.75%,和47.92%,分别)。BC-EIS组的胸骨后疼痛或不适略低于EVL组(23.4%,11/47vs.31.25%,15/48)。BC-EIS组和EVL组分别有2例和5例患者出现轻度腹胀和腹胀,分别(2/47,4.26%与5/48,10.42%P>0.05)。在bc-EIS组中有1例患者(1/47,2.13%),在EVL组中有3例患者(3/48,6.25%)报告了恶心和呕吐。然而,两组比较差异无统计学意义(P>0.05)。无致命或严重并发症,比如食管穿孔,食管狭窄或异位栓塞,被观察到。
结论:bc-EIS方法可有效根除电动汽车,且并发症少。
Herein, our group designed a novel technology, termed balloon compression-assisted endoscopic injection sclerotherapy (bc-EIS), which was applied to improve the efficiency of eradicating esophageal varices (EVs). The present study aimed to compare the rate of eradication and efficacy between bc-EIS and endoscopic variceal ligation (EVL) in the management of EVs.
Ninety-five patients with esophageal variceal bleeding (EVB) were randomly assigned to receive bc-EIS or ligation alone. Additional treatment sessions were held 1 month later and then at 3-month intervals until eradication of the varices was achieved. Endoscopic follow-up examinations were carried out at 6-month intervals in the absence of recurrence or immediately if there was any recurrent bleeding.
The mean physical injection points per session were 2.89 ± 0.79, and the mean volume of lauromacrogol used per session was 17.74 ± 7.09 ml in the bc-EIS group. The mean band per session was 6.13 ± 0.86. The rate of eradication after one to three rounds of bc-EIS was obviously higher than that of the EVL group (89.36%, 97.87%, and 100% vs. 37.5%, 43.75%, and 47.92%, respectively). Retrosternal pain or discomfort in the bc-EIS group was slightly lower than that in the EVL group (23.4%, 11/47 vs. 31.25%, 15/48). Two and five patients showed mild abdominal bloating and distension between the bc-EIS and EVL groups, respectively (2/47, 4.26% vs. 5/48, 10.42% P > 0.05). Nausea and vomiting were reported in one patient (1/47, 2.13%) in the bc-EIS group and three patients (3/48, 6.25%) in the EVL group. However, there were no statistically significant differences between the two groups (P > 0.05). No fatal or severe complications, such as esophageal perforation, esophageal stricture or ectopic embolism, were observed.
The bc-EIS method was effective in eradicating EVs and was accompanied by fewer complications.