COVID-19疾病的流行在全球范围内造成了严重影响。各国政府认为疫苗接种是控制大流行的有效措施。然而,许多人一直在犹豫是否接种COVID-19疫苗,特别是围观和哺乳期妇女。尽管研究表明,患有COVID-19的孕妇出现不良妊娠和分娩结局的风险更高,以及严重的疾病。似乎缺乏系统和全面的证据表明,围概念和哺乳期妇女对COVID-19疫苗犹豫的患病率和决定因素。因此,有必要调查围概念和哺乳期妇女的疫苗接种观点和行为。这项研究将回顾有关围概念和哺乳期妇女疫苗犹豫的文章,以评估大流行期间COVID-19疫苗犹豫的影响。
我们将在以下数据库中系统地搜索2019年11月1日至2021年10月30日的观测研究:WebofScience,PubMed,EMBASE,MEDLINE,科克伦图书馆,EBSCO,世卫组织COVID-19数据库,CNKI与万方数据库将使用以下医学主题词和自由文本术语:“COVID-19疫苗”和“女性”和“疫苗犹豫”。资格标准如下:人口(育龄妇女);暴露(目前怀孕,哺乳期或试图怀孕);比较(一般女性没有怀孕前,妊娠或哺乳期)和结局(COVID-19疫苗犹豫率)。文章筛选和数据提取将由两名审查人员独立进行,任何差异将通过讨论解决。我们将使用I2统计数据来评估异质性,并在提供足够同质的研究时进行荟萃分析。我们将使用亚组和荟萃回归分析来探索异质性的潜在来源。
这项研究将使用已发表的数据,所以不需要道德批准。研究结果将通过发表在同行评审的期刊上传播。
CRD42021257511。
The pandemic of COVID-19 disease has caused severe impact globally. Governments consider vaccination as an effective measure to control pandemic. However, many people have been hesitant to receive COVID-19 vaccine, particularly periconceptional and lactating women. Although research has indicated that pregnant women with COVID-19 are at a higher risk of adverse pregnancy and birth outcomes, as well as severe illness. There appears to be a lack of systematic and comprehensive evidence of the prevalence and determinants of COVID-19 vaccine hesitancy among periconceptional and lactating women. As a result, it has been essential to investigate periconceptional and lactating women\'s vaccination views and behaviours. This study will review articles on vaccine hesitancy among periconceptional and lactating women to assess the impact of the COVID-19 vaccine hesitancy during the pandemic.
We will systematically search observational studies from 1 November 2019 to 30 October 2021 in the following databases: Web of Science, PubMed, EMBASE, MEDLINE, Cochrane Library, EBSCO, WHO COVID-19 Database, CNKI and WanFang Database. The following medical subject headings and free-text terms will be used: \"COVID-19 vaccines\" AND \"female\" AND \"vaccine hesitancy\". Eligibility criteria are as follows: population (women of reproductive age); exposure (currently pregnant, lactational or trying to get pregnant); comparison (general women who are not in preconception, gestation or lactation) and outcome (the rate of COVID-19 vaccine hesitancy). Article screening and data extraction will be undertaken independently by two reviewers, and any discrepancy will be resolved through discussion. We will use I2 statistics to assess heterogeneity and perform a meta-analysis when sufficiently homogeneous studies are provided. We will explore the potential sources of heterogeneity using subgroup and meta-regression analysis.
This study will use published data, so ethical approval is not required. The findings will be disseminated by publication in peer-reviewed journal(s).
CRD42021257511.