UNASSIGNED:观察心脏康复(CR)对多发性冠状动脉病变部分血运重建患者的影响,并探讨其可能的机制。
UNASSIGNED:共纳入400例冠状动脉多发病变患者,随机分为完全血运重建组和CR组,每组200例。在完全血运重建组中进行了彻底的靶病变血运重建,虽然它在CR组中部分完成,术后CR。所有患者均接受常规治疗。左心室舒张末期内径(LVEDD),左心室射血分数(LVEF),6分钟步行距离(6-MWD),生活质量分数,血清一氧化氮(NO)的安全性和水平,一氧化氮合酶(NOS),超氧化物歧化酶(SOD),观察两组训练前后血管内皮生长因子(VEGF)的变化。
UNASSIGNED:LVEDD没有显著差异,LVEF,6-MWD,生活质量分数,血清NO水平,NOS,SOD,两组训练前VEGF水平比较(p>0.05)。一年后,与完全血运重建组相比,CR组主要不良事件发生率下降(p>0.05);LVEDD降低,LVEF升高(p>0.05),6-MWD显著增加(p<0.05),生活质量评分较高(p<0.05),血清NO的水平,NOS,SOD明显增加,CR组血清VEGF水平明显下降(p<0.05)。同一组内存在显著差异,训练前后(p<0.05)。
未经评估:心脏康复训练,不增加不良事件的发生率,在多发性冠状动脉病变患者的部分血运重建后是有效和安全的,通过改善一氧化氮合酶系统和抗氧化系统,降低VEGF水平,在提高患者运动耐力和生活质量方面具有显著的临床优势。
UNASSIGNED: To observe the effect of cardiac rehabilitation (CR) in patients with partial revascularization performed on multiple coronary artery lesions and explore its possible mechanism.
UNASSIGNED: A total of 400 patients with multiple coronary artery lesions were enrolled and randomly divided into a complete revascularization group and a CR group, with 200 cases in each group. Target lesion revascularization was performed radically in the complete revascularization group, while it was partially completed in the CR group, and postoperative CR was performed. All the patients were put under conventional treatment. Left ventricular end diastolic dimension (LVEDD), left ventricular ejection fraction (LVEF), 6-minute walking distance (6-MWD), quality-of-life scores, safety and levels of serum nitric oxide (NO), nitric oxide synthase (NOS), superoxide dismutase (SOD), and vascular endothelial growth factor (VEGF) were evaluated and compared between two groups before and after training.
UNASSIGNED: There was no significant difference in LVEDD, LVEF, 6-MWD, quality-of-life scores, levels of serum NO, NOS, SOD, and VEGF between two groups before training (p>0.05). 1 year later, compared with the complete revascularization group, the occurrence of major adverse events in the CR group declined (p>0.05); the measurements of LVEDD decreased and LVEF increased (p>0.05), 6-MWD increased significantly (p<0.05), quality-of-life scores were higher (p<0.05), the levels of serum NO, NOS, and SOD increased noticeably, and the levels of serum VEGF decreased significantly in the CR group (p<0.05). There were significant differences within the same group, before and after training (p<0.05).
UNASSIGNED: Cardiac rehabilitation training, not increase in the incidence of adverse events, is effective and safe after partial revascularization in patients with multiple coronary artery lesions, which has notable clinical advantages in promoting patients\' exercise endurance and quality-of-life by improving the nitric oxide synthase system and antioxidant system and reducing the level of VEGF.