未经授权:诺曼协会(https://www.norman-network.com/)启动了NORMAN可疑名单交换(NORMAN-SLE;https://www。norman-network.com/nds/SLE/)于2015年在NORMAN通过质谱对环境水样进行非目标筛选的合作试验之后。从那以后,这种关于预计在环境中发生的化学品的信息交换,以及随附的专业知识和参考资料,已成为“可疑筛查”列表的宝贵知识库。NORMAN-SLE现在是公平的(Findable,可访问,互操作,可重复使用的)全球化学信息资源。
未经授权:NORMAN-SLE包含来自全球70多个贡献者的99个单独的可疑清单集合(截至2022年5月),共有超过100,000种独特物质。物质类别包括全氟烷基物质和多氟烷基物质(PFAS),制药,杀虫剂,天然毒素,欧洲REACH法规(EC:1272/2008)涵盖的高产量物质,新兴关注的优先污染物(CEC)和NORMAN合作伙伴的监管清单。几个列表侧重于在环境中检测到的具有各种来源和结构信息的转化产品(TP)和复杂特征。每个列表都可以单独下载。合并的,精选的集合也可以作为NORMAN物质数据库(NORMANSusDat)。NORMAN-SLE和NORMANSusdat都集成在NORMAN数据库系统(NDS)中。各个NORMAN-SLE列表通过Zenodo社区(https://zenodo.org/communities/norman-sle)接收数字对象标识符(DOI)和可追踪的版本,共有>40,000个独特的观点,>50,000次独特下载和40次引用(2022年5月)。NORMAN-SLE内容逐步集成到大型开放式化学数据库中,例如PubChem(https://pubchem。ncbi.nlm.nih.gov/)和美国环保署的CompTox化学品仪表板(https://comptox.epa.gov/dashboard/),允许进一步访问这些列表,以及这些资源提供的附加功能和计算属性。PubChem还整合了来自NORMAN-SLE的重要注释内容,包括一个分类浏览器(https://pubchem.ncbi.nlm.nih.gov/分类/#hid=101)。
UNASSIGNED:NORMAN-SLE提供专门的服务,用于在开放的环境社区中托管与环境社区相关的可疑筛查清单,公平的方式,允许与其他主要的化学资源整合。这些努力促进了科学家和监管机构之间的信息交流,支持范式向“一种物质”的转变,一种评估“方法。欢迎通过NORMAN-SLE网站(https://www.norman-network.com/nds/SLE/)。
UNASSIGNED:在线版本包含补充材料,可在10.1186/s12302-022-00680-6获得。
UNASSIGNED: The NORMAN Association (https://www.norman-network.com/) initiated the NORMAN Suspect List Exchange (NORMAN-SLE; https://www.norman-network.com/nds/SLE/) in 2015, following the NORMAN collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange of information on chemicals that are expected to occur in the environment, along with the accompanying expert knowledge and references, has become a valuable knowledge base for \"suspect screening\" lists. The NORMAN-SLE now serves as a FAIR (Findable, Accessible, Interoperable, Reusable) chemical information resource worldwide.
UNASSIGNED: The NORMAN-SLE contains 99 separate suspect list collections (as of May 2022) from over 70 contributors around the world, totalling over 100,000 unique substances. The substance classes include per- and polyfluoroalkyl substances (PFAS), pharmaceuticals, pesticides, natural toxins, high production volume substances covered under the European REACH regulation (EC: 1272/2008), priority contaminants of emerging concern (CECs) and regulatory lists from NORMAN partners. Several lists focus on transformation products (TPs) and complex features detected in the environment with various levels of provenance and structural information. Each list is available for separate download. The merged, curated collection is also available as the NORMAN Substance Database (NORMAN SusDat). Both the NORMAN-SLE and NORMAN SusDat are integrated within the NORMAN Database System (NDS). The individual NORMAN-SLE lists receive digital object identifiers (DOIs) and traceable versioning via a Zenodo community (https://zenodo.org/communities/norman-sle), with a total of > 40,000 unique views, > 50,000 unique downloads and 40 citations (May 2022). NORMAN-SLE content is progressively integrated into large open chemical databases such as PubChem (https://pubchem.ncbi.nlm.nih.gov/) and the US EPA\'s CompTox Chemicals Dashboard (https://comptox.epa.gov/dashboard/), enabling further access to these lists, along with the additional functionality and calculated properties these resources offer. PubChem has also integrated significant annotation content from the NORMAN-SLE, including a classification browser (https://pubchem.ncbi.nlm.nih.gov/classification/#hid=101).
UNASSIGNED: The NORMAN-SLE offers a specialized service for hosting suspect screening lists of relevance for the environmental community in an open, FAIR manner that allows integration with other major chemical resources. These efforts foster the exchange of information between scientists and regulators, supporting the paradigm shift to the \"one substance, one assessment\" approach. New submissions are welcome via the contacts provided on the NORMAN-SLE website (https://www.norman-network.com/nds/SLE/).
UNASSIGNED: The online version contains supplementary material available at 10.1186/s12302-022-00680-6.