Catheterization

导管插入术
  • 文章类型: English Abstract
    A total of 309 (138 males and 171 females) end-stage renal disease patients who underwent implantation of early cannulation arteriovenous grafts (Acuseal) for hemodialysis in Nanfang Hospital, Southern Medical University between December 2016 and May 2021 were retrospectively included. The age of patients was (61.5±10.3) years. There were 244 patients (119 males and 125 females) who received regular follow-up. During the follow-up period, 24 patients died. Perioperative complications included graft infection (4.5%, 11/244), hematoma (4.5%, 11/244) and steal syndrome (4.1%, 10/244). No seroma or anastomotic rupture occurred. The rates of the first postoperative puncture time within 24 h, 48 h and 72 h after implantation were 42.2%(103/244), 32.4% (79/244) and 16.4% (40/244), respectively. The Kaplan-Meier survival analysis showed that the primary patency rates at 6 months and 12 months were 66.5% and 48.4%, respectively, and the secondary patency rates at 6 months and 12 months were 96.7% and 91.8%, respectively. The current study indicates that the Acuseal graft is safe for vascular access in patients requiring hemodialysis, with satisfactory patency and acceptable complication rates at 1-year follow-up.
    回顾性分析2016年12月至2021年5月在南方医科大学南方医院因血液透析植入即穿型人工血管构建动静脉移植物内瘘的309例终末期肾病患者(男138例,女171例)的临床资料。患者年龄(61.5±10.3)岁,其中244例患者(男119例,女125例)得到规律随访。随访期间24例患者死亡。309例患者中围手术期并发症包括移植物感染11例(4.5%),穿刺相关血肿11例(4.5%),窃血综合征10例(4.1%),无血清肿、吻合口破裂及移植物内瘘血栓形成发生。植入人工血管后24、48、72 h内进行第1次穿刺透析的比例分别为42.2%(103/244)、32.4%(79/244)、16.4%(40/244)。Kaplan-Meier生存分析结果显示,6、12个月初级通畅率分别为66.5%、48.4%,6、12个月次级通畅率分别为96.7%、91.8%。本研究结果显示即穿型人工血管移植物可安全地用于终末期肾病患者作为血管通路,其中12个月的随访结果满意。.
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  • 文章类型: Journal Article
    背景:脑灌注可能根据动脉插管部位而变化,并可能影响心脏切开术后体外生命支持(ECLS)中神经系统不良事件的发生率。当前的研究将患者的神经系统结局与三种常用的动脉插管策略进行了比较(主动脉与锁骨下/腋窝vs.股动脉),以评估每种ECLS配置是否与神经系统并发症的不同发生率相关。
    方法:本回顾性研究,多中心(34个中心),观察性研究纳入了2000年1月至2020年12月期间需要进行心脏切开术后ECLS的成年人,该研究出现在心脏切开术后体外生命支持(PELS)研究数据库中.主动脉患者,比较锁骨下/腋下和股骨插管在复合神经系统终点(缺血性卒中,脑出血,脑水肿)。次要结局是总体住院死亡率,神经系统并发症是院内死亡的原因,和术后轻微的神经系统并发症(癫痫发作)。通过线性混合效应模型研究了插管与神经系统结局之间的关联。
    结果:这项研究包括1897名患者,其中主动脉占26.5%(n=503),20.9%锁骨下/腋下(n=397)和52.6%股骨(n=997)插管。锁骨下/腋下组的高血压病史更为频繁,吸烟,糖尿病,以前的心肌梗塞,透析,外周动脉疾病和既往卒中。神经监测在所有组中都很少使用。在混合效应模型调整后,锁骨下/腋下的主要神经系统并发症更为常见(主动脉:n=79,15.8%;锁骨下/腋下:n=78,19.6%;股骨:n=118,11.9%;p<0.001)(OR1.53[95%CI1.02-2.31],p=0.041)。癫痫发作在锁骨下/腋下(n=13,3.4%)比主动脉(n=9,1.8%)和股骨插管(n=12,1.3%,p=0.036)。主动脉插管后住院死亡率更高(主动脉:n=344,68.4%,锁骨下/腋下:n=223,56.2%,股骨:n=587,58.9%,p<0.001),如Kaplan-Meier曲线所示。总之,神经系统死亡原因(主动脉:n=12,3.9%,锁骨下/腋下:n=14,6.6%,股骨:n=28,5.0%,p=0.433)相似。
    结论:在PELS研究的分析中,锁骨下/腋下插管与较高的主要神经系统并发症和癫痫发作率相关。主动脉插管后住院死亡率较高,尽管这些患者的神经系统死亡原因发生率没有显着差异。这些结果鼓励对ECLS患者的神经系统并发症和神经监测使用保持警惕,尤其是锁骨下/腋下插管。
    BACKGROUND: Cerebral perfusion may change depending on arterial cannulation site and may affect the incidence of neurologic adverse events in post-cardiotomy extracorporeal life support (ECLS). The current study compares patients\' neurologic outcomes with three commonly used arterial cannulation strategies (aortic vs. subclavian/axillary vs. femoral artery) to evaluate if each ECLS configuration is associated with different rates of neurologic complications.
    METHODS: This retrospective, multicenter (34 centers), observational study included adults requiring post-cardiotomy ECLS between January 2000 and December 2020 present in the Post-Cardiotomy Extracorporeal Life Support (PELS) Study database. Patients with Aortic, Subclavian/Axillary and Femoral cannulation were compared on the incidence of a composite neurological end-point (ischemic stroke, cerebral hemorrhage, brain edema). Secondary outcomes were overall in-hospital mortality, neurologic complications as cause of in-hospital death, and post-operative minor neurologic complications (seizures). Association between cannulation and neurological outcomes were investigated through linear mixed-effects models.
    RESULTS: This study included 1897 patients comprising 26.5% Aortic (n = 503), 20.9% Subclavian/Axillary (n = 397) and 52.6% Femoral (n = 997) cannulations. The Subclavian/Axillary group featured a more frequent history of hypertension, smoking, diabetes, previous myocardial infarction, dialysis, peripheral artery disease and previous stroke. Neuro-monitoring was used infrequently in all groups. Major neurologic complications were more frequent in Subclavian/Axillary (Aortic: n = 79, 15.8%; Subclavian/Axillary: n = 78, 19.6%; Femoral: n = 118, 11.9%; p < 0.001) also after mixed-effects model adjustment (OR 1.53 [95% CI 1.02-2.31], p = 0.041). Seizures were more common in Subclavian/Axillary (n = 13, 3.4%) than Aortic (n = 9, 1.8%) and Femoral cannulation (n = 12, 1.3%, p = 0.036). In-hospital mortality was higher after Aortic cannulation (Aortic: n = 344, 68.4%, Subclavian/Axillary: n = 223, 56.2%, Femoral: n = 587, 58.9%, p < 0.001), as shown by Kaplan-Meier curves. Anyhow, neurologic cause of death (Aortic: n = 12, 3.9%, Subclavian/Axillary: n = 14, 6.6%, Femoral: n = 28, 5.0%, p = 0.433) was similar.
    CONCLUSIONS: In this analysis of the PELS Study, Subclavian/Axillary cannulation was associated with higher rates of major neurologic complications and seizures. In-hospital mortality was higher after Aortic cannulation, despite no significant differences in incidence of neurological cause of death in these patients. These results encourage vigilance for neurologic complications and neuromonitoring use in patients on ECLS, especially with Subclavian/Axillary cannulation.
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  • 文章类型: Journal Article
    中国大约有200万成人先天性心脏病患者,中度和重度患者的数量正在增加。然而,很少有研究调查导管插入后严重不良事件(SAE)的风险.这项研究的目的是确定与心导管插入相关的SAE的危险因素,并提供预测SAE的风险评分模型。
    回顾性收集2018年1月至2022年1月在武汉科技大学附属武汉亚洲心脏医院行心导管插入术的中重度成人先天性心脏病(ACHD)患者690例,随后分为建模组和验证组。对已识别的SAE危险因素进行了单变量分析,然后将显著因素纳入多因素logistic回归模型以筛选SAE的独立预测因子.受试者工作特性曲线(ROC)和Hosmer-Lemeshow试验用于评估模型的鉴别和校准,分别。
    符合纳入标准的690例导管插入手术中有69例(10.0%)发生SAE。建立的SAE风险计算公式为logit(p)=-6.1340.992×肺动脉高压(是)+1.459×疾病严重程度(严重)+2.324×手术类型(诊断和介入)+1.436×cTnI(≥0.028μg/L)+1.537×NT-proBNP(≥126.65pg/mL)。基于各预测因子效应大小的最终风险评分模型总分为0~7分,涉及肺动脉高压(1分),疾病严重程度(1分),程序类型(2分),cTnI(1分)和NT-proBNP(2分),得分大于3表示高风险。推导和验证队列的ROC曲线下面积的C统计量为0.840和0.911,分别。根据Hosmer-Lemeshow测试,模型组和验证组的p值分别为0.064和0.868.
    本研究建立的风险预测模型具有很高的辨别力和校准性,可为临床预测和评估中重度ACHD患者心导管术后SAE风险提供参考。
    UNASSIGNED: There are almost 2 million adult patients with congenital heart disease in China, and the number of moderate and severe patients is increasing. However, few studies have investigated the risk of serious adverse events (SAE) after catheterization among them. The aim of this study was to identify risk factors for SAE related to cardiac catheterization and to provide the risk scoring model for predicting SAE.
    UNASSIGNED: A total of 690 patients with moderate and severe adult patients with congenital heart disease (ACHD) who underwent cardiac catheterization in Wuhan Asian Heart Hospital Affiliated to Wuhan University of Science and Technology from January 2018 to January 2022 were retrospectively collected and subsequently divided into a modeling group and a verification group. A univariate analysis was performed on the identified SAE risk factors, and then significant factors were included in the multivariate logistic regression model to screen for independent predictors of SAE. The receiver operating characteristic curve (ROC) and the Hosmer-Lemeshow test were used to evaluate the discrimination and calibration of the model, respectively.
    UNASSIGNED: A SAE occurred in 69 (10.0%) of the 690 catheterization procedures meeting inclusion criteria. The established SAE risk calculation formula was logit(p) = -6.134 + 0.992 × pulmonary artery hypertension (yes) + 1.459 × disease severity (severe) + 2.324 × procedure type (diagnostic and interventional) + 1.436 × cTnI ( ≥ 0.028 μ g/L) + 1.537 × NT-proBNP ( ≥ 126.65 pg/mL). The total score of the final risk score model based on the effect size of each predictor was 0 to 7, involving pulmonary artery hypertension (1 point), disease severity (1 point), procedure type (2 points), cTnI (1 point) and NT-proBNP (2 points), and the score greater than 3 means high risk. The C-statistic of the area under the ROC curve was 0.840 and 0.911 for the derivation and validation cohorts, respectively. According to the Hosmer-Lemeshow test, the p values in the modeling group and the verification group were 0.064 and 0.868, respectively.
    UNASSIGNED: The risk prediction model developed in this study has high discrimination and calibration, which can provide reference for clinical prediction and evaluation of SAE risk after cardiac catheterization in patients with moderate and severe ACHD.
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  • 文章类型: Journal Article
    本研究旨在使用患者特征和导管插入技术特征变量来训练相应的机器学习(ML)模型,以预测外周中心静脉导管-深静脉血栓形成(PICCs-DVT),并从“输入-输出”相关性方面分析这两种特征对PICCs-DVT的重要性。全面系统地总结用于描述患者特征和导管插入技术特征的变量,本研究结合了18篇涉及预测PICCs-DVT的两种特征的文献.总结了用于描述这两种类型特征的总共21个变量,和特征值从2021年1月1日至2022年8月31日的1,065名PICCs患者数据中提取,构建数据样本集。然后,70%的样本集用于模型训练和超参数优化,并将30%的样本集用于三种常见ML分类模型(即支持向量分类器[SVC]、随机森林[RF],和人工神经网络[ANN])。在预测性能方面,本研究选择了四个指标来评估模型的预测性能:精度(P),召回(R),精度(ACC),和曲线下面积(AUC)。在特征重要性分析方面,本研究选择了一种基于“输入-输出”灵敏度原理-排列重要性的单一特征分析方法。对于平均模型性能,测试集上的三个ML模型分别为P=0.92、R=0.95、ACC=0.88和AUC=0.81。具体来说,RF模型为P=0.95,R=0.96,ACC=0.92,AUC=0.86;ANN模型为P=0.92,R=0.95,ACC=0.88,AUC=0.81;SVC模型为P=0.88,R=0.94,ACC=0.85,AUC=0.77。对于特征重要性分析,导管至静脉率(RF:91.55%,ANN:82.25%,SVC:87.71%),Zubrod-ECOG-WHO评分(RF:66.35%,ANN:82.25%,SVC:44.35%),和插入尝试(射频:44.35%,ANN:37.65%,SVC:65.80%)在PICCs-DVT的ML模型预测任务中均占据前三名,显示出相对一致的排名结果。ML模型在预测PICC-DVT方面表现出良好的性能,并从数据中揭示了特征重要性的相对一致的排名。揭示的重要特征可能有助于临床医务人员从数据驱动的角度更好地理解和分析PICC-DVT的形成机制。
    This study aims to use patient feature and catheterization technology feature variables to train the corresponding machine learning (ML) models to predict peripherally inserted central catheters-deep vein thrombosis (PICCs-DVT) and analyze the importance of the two types of features to PICCs-DVT from the aspect of \"input-output\" correlation. To comprehensively and systematically summarize the variables used to describe patient features and catheterization technical features, this study combined 18 literature involving the two types of features in predicting PICCs-DVT. A total of 21 variables used to describe the two types of features were summarized, and feature values were extracted from the data of 1,065 PICCs patients from January 1, 2021 to August 31, 2022, to construct a data sample set. Then, 70% of the sample set is used for model training and hyperparameter optimization, and 30% of the sample set is used for PICCs-DVT prediction and feature importance analysis of three common ML classification models (i.e. support vector classifier [SVC], random forest [RF], and artificial neural network [ANN]). In terms of prediction performance, this study selected four metrics to evaluate the prediction performance of the model: precision (P), recall (R), accuracy (ACC), and area under the curve (AUC). In terms of feature importance analysis, this study chooses a single feature analysis method based on the \"input-output\" sensitivity principle-Permutation Importance. For the mean model performance, the three ML models on the test set are P = 0.92, R = 0.95, ACC = 0.88, and AUC = 0.81. Specifically, the RF model is P = 0.95, R = 0.96, ACC = 0.92, AUC = 0.86; the ANN model is P = 0.92, R = 0.95, ACC = 0.88, AUC = 0.81; the SVC model is P = 0.88, R = 0.94, ACC = 0.85, AUC = 0.77. For feature importance analysis, Catheter-to-vein rate (RF: 91.55%, ANN: 82.25%, SVC: 87.71%), Zubrod-ECOG-WHO score (RF: 66.35%, ANN: 82.25%, SVC: 44.35%), and insertion attempt (RF: 44.35%, ANN: 37.65%, SVC: 65.80%) all occupy the top three in the ML models prediction task of PICCs-DVT, showing relatively consistent ranking results. The ML models show good performance in predicting PICCs-DVT and reveal a relatively consistent ranking of feature importance from the data. The important features revealed might help clinical medical staff to better understand and analyze the formation mechanism of PICCs-DVT from a data-driven perspective.
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  • 文章类型: Case Reports
    背景:Chiari网络,胎儿解剖结构的残余部分,由右心房内的网状结构组成。随着心脏干预的进步,与Chiari网络相关的并发症的报道越来越多.然而,在插入透析导管时,很少有关于Chiari网络中导丝或导管截留的报道.
    方法:一名患有终末期肾病的46岁男性住院,并接受了数字减影血管造影辅助的右颈内静脉隧道袖套透析导管插入术。当导丝进入约20厘米的深度时,很难推进,表现为扭转导丝时的阻力和无法进入下腔静脉。插入可剥离鞘后,很难拔出导丝。反复尝试旋转导丝后,导丝终于被拔出。纤维组织缠绕在导丝的尖端周围。它的长度是6厘米,具有光滑的表面和坚韧的纹理。我们认为我们取出的组织很可能是Chiari网络的一部分。
    结论:这个案例突出了Chiari网络使外科手术复杂化的可能性,包括导丝和导管操作困难。应该注意Chiari网络。超声心动图可用于识别Chiari网络。在手术过程中,不建议强行拉出卡住的导丝,以避免撕裂心房壁和引起心包填塞的风险。在这种情况下,与超声医生和心脏外科医生的紧急咨询可能会有所帮助。
    BACKGROUND: The Chiari network, a remnant of fetal anatomy, consists of a mesh-like structure within the right atrium. With advancements in cardiac interventions, complications associated with the Chiari network have increasingly been reported. However, there are few reports about guidewire or catheter entrapment in the Chiari network during the insertion of a dialysis catheter.
    METHODS: A 46-year-old male with end-stage renal disease was hospitalized and underwent a digital subtraction angiography-assisted catheterization of the right internal jugular vein tunnel-cuffed dialysis catheter. When the guide wire entered a depth of about 20 cm, it was difficult to advance, manifested as resistance when twisting the guide wire and inability to enter the inferior vena cava. After the peelable sheath was inserted, it was difficult to pull out the guide wire. After repeated attempts to rotate the guide wire, the guide wire was finally pulled out. A fibrous tissue was wrapped around the tip of the guide wire. Its length was 6 cm, with a smooth surface and tough texture. We considered that the tissue we pulled out was most likely a part of a Chiari network.
    CONCLUSIONS: This case highlights the potential for the Chiari network to complicate surgical procedures, including difficulty with guidewire and catheter manipulation. Attention should be paid to Chiari networks. Echocardiography can be used to identify the Chiari network. During the surgery, forcefully pulling out a stuck guidewire is not suggested, to avoid the risk of tearing the atrial wall and causing pericardial tamponade. An urgent consultation with ultrasound doctors and cardiac surgeons might be helpful in such cases.
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  • 文章类型: Journal Article
    右心衰竭是心脏手术后常见的并发症,其死亡率仍然很高。在大多数情况下,医疗管理和静脉动脉体外膜氧合已显示出显着改善。然而,少数患者可能仍需要长期的机械循环支持或心脏移植.气囊式房间隔造口术是预防和治疗右心衰竭的新方法。这可以避免患者对机械循环支持的依赖。我们用这种方法尝试治疗心脏手术后右心衰竭的患者,所有人都得到了很好的好处。因此,我们选择了几个有代表性的案例来报告,以指导其他合格的心脏外科医生开展相关的临床实践。
    Right heart failure is a common complication after cardiac surgery, and its mortality remains high. The medical management and veno-arterial extracorporeal membrane oxygenation has shown significant improvement in the majority of cases. However, a minority of patients may still require long-term mechanical circulatory support or heart transplantation. Balloon atrial septostomy is a new method for the prevention and treatment of right heart failure, which may avoid the patient\'s dependence on mechanical circulatory support. We used this method to try to treat patients with right heart failure after cardiac surgery, and all received good benefits. Therefore, we selected several representative cases to report, in order to guide other qualified cardiac surgeons to carry out relevant clinical practice.
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  • 文章类型: Journal Article
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  • 文章类型: Editorial
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  • 文章类型: Journal Article
    在接受肾移植(RT)的终末期肾病(ESRD)患者中,导管相关性膀胱不适(CRBD)的发生率相对较高。本研究旨在建立ESRD患者RT后CRBD预测的列线图。
    在这项回顾性研究中,我们收集了2019年9月至2023年8月在我院接受RT的269例ESRD患者.基于8:2的比率将患者分为训练集(n=215)和测试集(n=54)。单变量和多变量逻辑回归分析用于确定RT后与CRBD相关的危险因素。然后建立了列线图模型。使用接收器工作特性(ROC)和校准曲线来评估已建立的列线图的预测效率。
    多变量逻辑回归分析显示异常体重指数(BMI)(体重不足:OR=5.25;95%CI[1.25-22.15],P=0.024;超重:OR=2.75;95%CI[1.17-6.49],P=0.021),无尿(OR=2.86;95%CI[1.33-5.88])和应用直径>5Fr的双J(DJ)支架(OR=15.88;95%CI[6.47-39.01],P<0.001)是RT后CRBD的独立危险因素。相比之下,舒芬太尼利用率(>100µg)[OR=0.39;95%CI[0.17-0.88],P=0.023]与CRBD发生率降低相关。然后基于这些参数建立用于预测RT后CRBD发生的列线图。ROC曲线下面积(AUC)值和校准曲线证实了列线图的预测效率。
    建立了一个列线图,用于预测ESRD患者RT后的CRBD,根据AUC和校准曲线显示出良好的预测效率。
    UNASSIGNED: The incidence of catheter-related bladder discomfort (CRBD) is relatively high in the end-stage renal disease (ESRD) patients who underwent renal transplantation (RT). This study was designed to establish a nomogram for predicting CRBD after RT among ESRD patients.
    UNASSIGNED: In this retrospective study, we collected 269 ESRD patients who underwent RT between September 2019 and August 2023 in our hospital. The patients were divided into training set (n = 215) and test set (n = 54) based on a ratio of 8:2. Univariate and multivariate logistic regression analyses were utilized to identify the risk factors associated with CRBD after RT, and then a nomogram model was constructed. Receiver operating characteristic (ROC) and calibration curve were used to evaluate the predicting efficiency of the established nomogram.
    UNASSIGNED: Multivariate logistic regression analysis showed that aberrant body mass index (BMI) (underweight: OR = 5.25; 95% CI [1.25-22.15], P = 0.024; overweight: OR = 2.75; 95% CI [1.17-6.49], P = 0.021), anuria (OR = 2.86; 95% CI [1.33-5.88]) and application of double J (DJ) stent with a diameter of >5Fr (OR = 15.88; 95% CI [6.47-39.01], P < 0.001) were independent risk factors for CRBD after RT. In contrast, sufentanil utilization (>100 µg) [OR = 0.39; 95% CI [0.17-0.88], P = 0.023] was associated with decreased incidence of CRBD. A nomogram was then established based on these parameters for predicting the occurrence of CRBD after RT. Area under the ROC curve (AUC) values and calibration curves confirmed the prediction efficiency of the nomogram.
    UNASSIGNED: A nomogram was established for predicting CRBD after RT in ESRD patients, which showed good prediction efficiency based on AUC and calibration curves.
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  • 文章类型: Journal Article
    目的:导尿是产后尿潴留(PUR)的常用治疗方法;其在PUR诊断前的应用尚不清楚。目的是概述有关产时或产后导尿预防PUR的有效性和安全性的现有文献。
    方法:本范围审查遵循一个方法论框架。PubMed,Cochrane图书馆,Embase,WebofScience,中国国家知识基础设施,万方,中国科技期刊数据库,从每个数据库开始到2023年5月21日,检索了中国生物医学文献数据库。
    结果:搜索显示16项研究检查了三种不同的导管插入方法,包括12项产时研究。十项研究得出结论,产时或产后导管插入术可预防PUR,其中两个仅用于公开或秘密PUR。13项实验研究中有4项,没有发现显着差异:一个用于产时导管插入术与常规护理,另一种用于产时或产后间歇性与留置导尿。然而,一项研究发现,与留置导尿相比,无效针对性护理后的产后一次性导尿降低了PUR的发生率.3项病例对照研究中的一项得出结论,产前导管插入≥2次是PUR的危险因素。
    结论:根据本范围审查的结果,在诊断PUR之前进行导管检查似乎在预防PUR中起作用并且是安全的.初步证据表明,三种导管插入方法在预防PUR方面的有效性正在积累,但是需要更全面的研究来确定这些发现。
    OBJECTIVE: Catheterization is a common treatment for postpartum urinary retention (PUR); however, its application before diagnosis of PUR remains unclear. The aim was to give an overview of the existing literature on the effectiveness and safety of intrapartum or postpartum catheterization in the prevention of PUR.
    METHODS: This scoping review followed a methodological framework. PubMed, the Cochrane Library, Embase, Web of Science, the China National Knowledge Infrastructure, WanFang, the China Science and Technology Journal Database, and the China Biomedical Literature Database were searched from the inception of each database to 21 May 2023.
    RESULTS: The search revealed 16 studies examining three different catheterization methodologies, including 12 intrapartum studies. Ten studies concluded that intrapartum or postpartum catheterization prevented PUR, two of which were only for overt or covert PUR. In 4 out of 13 experimental studies, no significant difference was found: one for intrapartum catheterization versus routine nursing, the other for intrapartum or postpartum intermittent versus indwelling catheterization. However, one found that postpartum disposable catheterization after ineffective targeted care reduced the incidence of PUR compared with indwelling catheterization. One out of the 3 case-control studies concluded that prenatal catheterization ≥2 times was a risk factor for PUR.
    CONCLUSIONS: Based on the findings in this scoping review, catheterization prior to the diagnosis of PUR appears to play a role in preventing PUR and is safe. Preliminary evidence is accumulating on the effectiveness of three types of catheterization methods in preventing PUR, but more comprehensive studies are needed to establish these findings.
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