目的:本研究探讨了合成MRI(SyMRI)对先天性心脏病(CHD)患儿术前脑发育的定量评估和应用。
方法:前瞻性将43例2~24个月的冠心病患者纳入观察组,43例健康婴儿纳入对照组。通过后处理软件处理SyMRI扫描以获得T1,T2和PD图。采用Pearson相关性分析比较不同脑区T1、T2、PD值与Gesell发育量表五个能力区评分。
结果:在观察组中,内囊后肢的T1值(PLIC),光学辐射(PTR),脑梗,半谷中心,枕骨白质,颞叶白质,齿状核大于对照组。在观察组中,PLIC的T2值,PTR,额叶白质,枕骨白质,颞叶白质,齿状核大于对照组。Pearson相关分析显示,观察组的发展量表评分明显较低。在观察组中,call体spenium的T2值与个人社会行为得分呈显着正相关。使用颞白质和齿状核的T1值诊断CHD儿童术前脑发育异常的AUC均大于0.60。
结论:使用SyMRI进行定量评估可以帮助早期发现冠心病患儿术前大脑发育异常。
■来自SyMRI的T1和T2弛豫值可以视为定量成像标记,以检测异常,允许早期临床评估和及时干预,从而减少这些儿童的神经发育障碍。
结论:SyMRI的T1和T2弛豫值与髓鞘发育有关。与对照组相比,在观察中评估的发育商标记较低。SyMRI可以作为CHD儿童脑发育的参考指标。
OBJECTIVE: This study investigated the quantitative assessment and application of Synthetic MRI (SyMRI) for preoperative brain development in children with congenital heart disease (CHD).
METHODS: Forty-three CHD patients aged 2-24 months were prospectively included in the observation group, and 43 healthy infants were included in the control group. The SyMRI scans were processed by postprocessing software to obtain T1, T2, and PD maps. The values of T1, T2, and PD in different brain regions were compared with the scores of the five ability areas of the Gesell Development Scale by Pearson correlation analysis.
RESULTS: In the observation group, the T1 values of the posterior limb of the internal capsule (PLIC), Optic radiation (PTR), cerebral peduncle, centrum semiovale, occipital white matter, temporal white matter, and dentate nucleus were greater than those in the control group. In the observation group, the T2 values of the PLIC, PTR, frontal white matter, occipital white matter, temporal white matter, and dentate nucleus were greater than those in the control group. Pearson correlation analysis revealed that the observation group had significantly lower Development Scale scores. In the observation group, the T2 value of the splenium of the corpus callosum was significantly positively correlated with the personal social behavior score. The AUCs for diagnosing preoperative brain developmental abnormalities in children with CHD using T1 values of the temporal white matter and dentate nucleus were both greater than 0.60.
CONCLUSIONS: Quantitative assessment using SyMRI can aid in the early detection of preoperative brain development abnormalities in children with CHD.
UNASSIGNED: T1 and T2 relaxation values from SyMRI can be considered as a quantitative imaging marker to detect abnormalities, allowing for early clinical evaluation and timely intervention, thereby reducing neurodevelopmental disorders in these children.
CONCLUSIONS: T1 and T2 relaxation values by SyMRI are related to myelin development. Evaluated development quotient markers were lower in the observation compared to the control group. SyMRI can act as a reference indicator for brain development in CHD children.