目的:功能性便秘(FC),一种常见的功能性胃肠病,通常与上消化道症状(UGS)重叠。我们旨在探讨FC重叠UGS患者的临床特征以及相关危险因素。
方法:便秘症状严重程度的差异,心理状态,生活质量(QoL),肛门直肠运动和感知功能,自主神经功能,分析不同组FC患者的生物反馈治疗(BFT)效果,以及重叠UGS的风险因素。
结果:与单纯FC患者相比,FC重叠UGS的患者在便秘症状评估和焦虑自评量表中得分较高,在ShortForm-36健康调查中得分较低(P<0.05).FC重叠UGS的患者直肠推进也较低,更消极的自主神经功能,BFT疗效较差(P<0.05)。重叠UGS,尤其是重叠的功能性消化不良,严重影响了FC的严重程度。Logistic回归模型显示,年龄,体重指数(BMI),焦虑,锻炼,睡眠质量是影响FC患者重叠UGS的独立因素。
结论:重叠UGS会降低FC患者的身心健康和QoL。这也增加了FC治疗的难度。病人的年龄,BMI,焦虑,体育锻炼,睡眠质量可能是FC重叠UGS的预测因子。
OBJECTIVE: Functional constipation (FC), a common functional gastrointestinal disorder, is usually overlapping with upper gastrointestinal symptoms (UGS). We aimed to explore the clinical characteristics of patients with FC overlapping UGS along with the related risk factors.
METHODS: The differences in the severity of constipation symptoms, psychological state, quality of life (QoL), anorectal motility and perception function, autonomic function, and the effect of biofeedback therapy (BFT) among patients with FC in different groups were analyzed, along with the risk factors of overlapping UGS.
RESULTS: Compared with patients with FC alone, those with FC overlapping UGS had higher scores in the Patient Assessment of Constipation Symptoms and Self-Rating Anxiety Scale and lower scores in the Short Form-36 health survey (P < 0.05). Patients with FC overlapping UGS also had lower rectal propulsion, more negative autonomic nervous function, and worse BFT efficacy (P < 0.05). Overlapping UGS, especially overlapping functional dyspepsia, considerably affected the severity of FC. Logistic regression model showed that age, body mass index (BMI), anxiety, exercise, and sleep quality were independent factors influencing overlapping UGS in patients with FC.
CONCLUSIONS: Overlapping UGS reduces the physical and mental health and the QoL of patients with FC. It also increases the difficulty in the treatment of FC. Patient\'s age, BMI, anxiety, physical exercise, and sleep quality might be predictors for FC overlapping UGS.