Despite the rapid development of mobile health based on wearable devices in recent years, lack of access to biochemical detection remains a vital challenge for most commercial wearable devices, which hinders the provision of effective electronic health records (EHRs) for disease control strategies, and further constraining the development of personalized precision medicine. Herein, we propose a strategy to graft biochemical detection function onto commercial bracelet. Different from the conventional development process of designing a completely new wearable biochemical device, we prefer to upgrade existing commercial wearable device to achieve simpler, faster, and more effective research and commercialization processes. An affordable and user-friendly biochemical button module has been designed that enables to integrate sensitive, specific, and rapid biochemical detection function into the idle space on the strap of the bracelet without increasing the size of the main body. This \"Smart Bracelet Plus\" shows the ability to simultaneously monitor physical and biochemical signals, and will serve as a reliable and systematic personal diagnostics and monitoring platform for providing real-time EHRs for disease control strategies and improving the efficiency of the healthcare system.

Graphene remains of great interest in biomedical applications because of biocompatibility. Diseases relating to human senses interfere with life satisfaction and happiness. Therefore, the restoration by artificial organs or sensory devices may bring a bright future by the recovery of senses in patients. In this review, we update the most recent progress in graphene based sensors for mimicking human senses such as artificial retina for image sensors, artificial eardrums, gas sensors, chemical sensors, and tactile sensors. The brain-like processors are discussed based on conventional transistors as well as memristor related neuromorphic computing. The brain-machine interface is introduced for providing a single pathway. Besides, the artificial muscles based on graphene are summarized in the means of actuators in order to react to the physical world. Future opportunities remain for elevating the performances of human-like sensors and their clinical applications.

Nano biochemical sensors play an important role in detecting the biomarkers related to human diseases, and carbon nanotubes (CNTs) have become an important factor in promoting the vigorous development of this field due to their special structure and excellent electronic properties. This paper focuses on applying carbon nanotube field-effect transistor (CNT-FET) biochemical sensors to detect biomarkers. Firstly, the preparation method, physical and electronic properties and functional modification of CNTs are introduced. Then, the configuration and sensing mechanism of CNT-FETs are introduced. Finally, the latest progress in detecting nucleic acids, proteins, cells, gases and ions based on CNT-FET sensors is summarized.

This review provides a critical overview of current developments on nanoelectronic biochemical sensors based on graphene. Composed of a single layer of conjugated carbon atoms, graphene has outstanding high carrier mobility and low intrinsic electrical noise, but a chemically inert surface. Surface functionalization is therefore crucial to unravel graphene sensitivity and selectivity for the detection of targeted analytes. To achieve optimal performance of graphene transistors for biochemical sensing, the tuning of the graphene surface properties via surface functionalization and passivation is highlighted, as well as the tuning of its electrical operation by utilizing multifrequency ambipolar configuration and a high frequency measurement scheme to overcome the Debye screening to achieve low noise and highly sensitive detection. Potential applications and prospectives of ultrasensitive graphene electronic biochemical sensors ranging from environmental monitoring and food safety, healthcare and medical diagnosis, to life science research, are presented as well.