■骨形态发生蛋白(BMPs)在肿瘤的发生和转移中起着至关重要的作用。关于BMP及其拮抗剂在乳腺癌(BC)中的确切含义仍存在争议,由于其多样化和复杂的生物学功能和信号。引发了对整个家庭及其在乳腺癌中的信号的全面研究。
■BMP的异常表达,通过使用TCGA-BRCA和E-MTAB-6703组分析乳腺癌原发性肿瘤中的BMP受体和拮抗剂。相关生物标志物包括ER,她,扩散,入侵,血管生成,淋巴管生成和骨转移参与确定乳腺癌与BMPs的关系。
■本研究显示BMP8B在乳腺肿瘤中显著增加,而BMP6和ACVRL1在乳腺癌组织中降低。BMP2,BMP6,TGFBR1和GREM1的表达与BC患者的总体生存率显着相关。BMP的异常表达,与BMP受体一起,根据ER在不同亚型的乳腺癌中进行了探索,PR和HER2状态。此外,在三阴性乳腺癌(TNBC)中发现较高水平的BMP2,BMP6和GDF5,而BMP4,GDF15,ACVR1B,ACVR2B和BMPR1B在管腔型BC中相对较高。ACVR1B和BMPR1B与ERα呈正相关,与ERβ呈负相关。GDF15、BMP4和ACVR1B的高表达与HER2阳性BC中较差的总生存期相关。BMP在BC的肿瘤生长和转移中也起着双重作用。
■在不同亚型的乳腺癌中显示BMP的移位模式,提示亚型特异性受累。它激发了更多的研究来揭示这些BMP和受体通过调节增殖在疾病进展和远处转移中的确切作用,入侵和EMT。
UNASSIGNED: Bone morphogenetic proteins (BMPs) play crucial roles in the tumorigenesis and metastasis of cancers. Controversy remains about the exact implications of BMPs and their antagonists in breast cancer (BC), due to their diverse and complex biological functions and signalling. A comprehensive study of the whole family and their signalling in breast cancer is provoked.
UNASSIGNED: Aberrant expression of
BMP,
BMP receptors and antagonists in primary tumours in breast cancer were analysed by using TCGA-BRCA and E-MTAB-6703 cohorts. Related biomarkers including ER, HER, proliferation, invasion, angiogenesis, lymphangiogenesis and bone metastasis were involved to identify the relationship with BMPs in breast cancer.
UNASSIGNED: The present study showed BMP8B was significantly increased in breast tumours, while BMP6 and ACVRL1 were decreased in breast cancer tissues. The expressions of BMP2, BMP6, TGFBR1 and GREM1 were significantly correlated with BC patients\' poor overall survival. Aberrant expression of BMPs, together with
BMP receptors, were explored in different subtypes of breast cancer according to ER, PR and HER2 status. Furthermore, higher levels of BMP2, BMP6 and GDF5 were revealed in triple negative breast cancer (TNBC) whilst BMP4, GDF15, ACVR1B, ACVR2B and BMPR1B were relatively higher in Luminal type BC. ACVR1B and BMPR1B were positively correlated with ERα but were inversely correlated with ERβ. High expression of GDF15, BMP4 and ACVR1B were associated with poorer overall survival in HER2 positive BC. BMPs also play dual roles in tumour growth and metastasis of BC.
UNASSIGNED: A shift pattern of BMPs was showed in different subtypes of breast cancer suggesting a subtype specific involvement. It provokes more research to shed light on the exact role of these BMPs and receptors in the disease progression and distant metastasis through a regulation of proliferation, invasion and EMT.