评估中国中部地区揉眼和特应性对圆锥角膜(KC)的独立和交互影响。
病例对照研究共招募了330名KC患者和330名对照。通过面对面的访谈记录眼睛摩擦和特应性病史。KC和揉眼之间的联系,atopy,用logistic回归分析了揉眼和过敏的交互作用,和赔率比(OR),相互作用导致的相对超额风险(RERI),归因比例(AP),协同(S)指数,计算95%置信区间(95%CI)。
共有228例患者(69.09%)有擦眼史,KC组53例(16.06%)有特应性病史,均高于对照组(p<0.001)。在多变量分析中,眼部摩擦和特应性与KC呈正相关,OR(95%CI)为15.11(10.02,22.80)和5.30(2.59,10.84),分别。与非眼睛摩擦和非过敏眼睛相比,擦眼与特应性并存的风险为52.31(12.25,223.35).在KC和乘法相互作用之间没有发现显着关联(p=0.608)。RERI,AP,S值为32.89(-43.35,109.14),0.63(0.05,1.21),和2.79(0.56,13.96),分别,加性相互作用与KC之间没有显着关联。没有发现眼睛摩擦之间的显著关联,特应性和KC的严重程度(p>0.05)。
擦眼和特应性分别与KC呈正相关,在中国,擦眼和过敏共存对KC的影响很大。需要进行进一步的多中心和队列研究,以探讨揉眼和特应性在KC发生和发展中的作用。
To evaluate the independent and interactive effects of eye rubbing and atopy on keratoconus (KC) in central
China.
A total of 330 KC patients and 330 controls were recruited in the case-control study. Eye rubbing and history of
atopy were recorded through face-to-face interviews. The association between KC and eye rubbing,
atopy, interactive effects of eye rubbing and
atopy were analyzed by logistic regression, and the odds ratios (OR), relative excess risk due to interaction (RERI), attributable proportion (AP), synergy (S) index, and 95% confidence intervals (95% CI) were calculated.
A total of 228 patients (69.09%) had an eye rubbing history, and 53 (16.06%) had an atopy history in the KC group, which were both higher than that in the control group (p<0.001). Eye rubbing and atopy were positively associated with KC in multivariate analysis, with ORs (95% CIs) of 15.11 (10.02, 22.80) and 5.30 (2.59, 10.84), respectively. Compared to non-eye rubbing and non-
atopy eyes, the risk for eye rubbing coexisted with
atopy was 52.31 (12.25, 223.35). No significant associations were found between KC and multiplicative interaction (p=0.608). The RERI, AP, and S values were 32.89 (-43.35, 109.14), 0.63 (0.05, 1.21), and 2.79 (0.56, 13.96), respectively, with no significant association between additive interaction and KC. No significant associations were found between eye rubbing, atopy and the severity of KC (p>0.05).
Eye rubbing and atopy were separately positively associated with KC, and there was a strong impact of coexistent eye rubbing and atopy on KC in
China. Further multi-center and cohort study need to be conducted to explore the role of eye rubbing and atopy in the occurrence and development of KC.