Abstract：
BACKGROUND: Acute urticaria (AU) may be associated with atopy, but the relationship between atopic status and the clinical features of the disease has not been fully described.
OBJECTIVE: The aim of the study was to determine the proportion of atopy in AU patients and to see whether atopy is related to the clinical characteristics of AU and whether it has an impact on the outcome of the disease.
METHODS: A retrospective analysis of patients with AU was performed. Demographic data, clinical features, and laboratory results were compared and analyzed between the atopic and non-atopic AU (napAU).
RESULTS: In total, 139 participants were included. 54 (38.8%) patients were atopic AU (apAU) and 85 (61.2%) were napAU. Compared with napAU patients, apAU patients were more likely to have anaphylaxis, higher levels of C4, and lower levels of antistreptolysin. There were no significant differences between the two groups in terms of other clinical features, laboratory tests, the natural course of the disease, or disease outcomes.
CONCLUSIONS: Atopy does exist in some patients with AU, and AU patients with an atopic background are at higher risk for anaphylaxis. Atopy does not influence the clinical outcome of AU and is not correlated with other clinical features and laboratory results of AU.
OBJECTIVE: The aim of the study was to determine the proportion of atopy in AU patients and to see whether atopy is related to the clinical characteristics of AU and whether it has an impact on the outcome of the disease.
METHODS: A retrospective analysis of patients with AU was performed. Demographic data, clinical features, and laboratory results were compared and analyzed between the atopic and non-atopic AU (napAU).
RESULTS: In total, 139 participants were included. 54 (38.8%) patients were atopic AU (apAU) and 85 (61.2%) were napAU. Compared with napAU patients, apAU patients were more likely to have anaphylaxis, higher levels of C4, and lower levels of antistreptolysin. There were no significant differences between the two groups in terms of other clinical features, laboratory tests, the natural course of the disease, or disease outcomes.
CONCLUSIONS: Atopy does exist in some patients with AU, and AU patients with an atopic background are at higher risk for anaphylaxis. Atopy does not influence the clinical outcome of AU and is not correlated with other clinical features and laboratory results of AU.
摘要：
背景：急性荨麻疹（AU）可能与特应性有关，但是，特应性状态与疾病的临床特征之间的关系尚未得到充分描述。
目的：本研究的目的是确定AU患者中特应性疾病的比例，并观察特应性疾病是否与AU的临床特征有关，以及是否对疾病的结局有影响。
方法：对AU患者进行回顾性分析。人口统计数据,临床特征,并对特应性和非特应性AU（napAU）的实验室结果进行了比较和分析。
结果：总计，139名参与者参与其中。54例(38.8%)患者为特应性AU(apAU)，85例(61.2%)为napAU。与napAU患者相比，apAU患者更有可能出现过敏反应，较高水平的C4和较低水平的抗链球菌溶血素。两组在其他临床特征方面无显著差异,实验室测试,疾病的自然进程，或疾病结果。
结论：一些AU患者确实存在特应性，特应性背景的AU患者发生过敏反应的风险更高。特应性不影响AU的临床结果，并且与AU的其他临床特征和实验室结果无关。
目的：本研究的目的是确定AU患者中特应性疾病的比例，并观察特应性疾病是否与AU的临床特征有关，以及是否对疾病的结局有影响。
方法：对AU患者进行回顾性分析。人口统计数据,临床特征,并对特应性和非特应性AU（napAU）的实验室结果进行了比较和分析。
结果：总计，139名参与者参与其中。54例(38.8%)患者为特应性AU(apAU)，85例(61.2%)为napAU。与napAU患者相比，apAU患者更有可能出现过敏反应，较高水平的C4和较低水平的抗链球菌溶血素。两组在其他临床特征方面无显著差异,实验室测试,疾病的自然进程，或疾病结果。
结论：一些AU患者确实存在特应性，特应性背景的AU患者发生过敏反应的风险更高。特应性不影响AU的临床结果，并且与AU的其他临床特征和实验室结果无关。
