背景:COVID-19后状况(PCC),也被称为“长科维德”,“的特点是持续的症状,对PCC患者的福祉产生负面影响。快感缺失(即,快乐能力降低)和社会心理功能受损是PCC患者的显着症状。我们旨在提供见解,以了解PCC患者的快感缺失和心理社会功能受损的影响。方法:这项事后分析使用了8周的数据,双盲,随机化,安慰剂对照试验,评估沃替西汀对PCC患者认知缺陷的影响(Clinicaltrials.gov标识符:NCT05047952)。共有147名符合条件的参与者被随机分配接受沃替西汀或匹配的安慰剂,为期八周的双盲治疗。我们的研究调查了快感缺失之间的关系,由Snaith-Hamilton快乐量表(SHAPS)评估,和心理社会功能,用COVID后功能状态(PCFS)量表测量。使用广义线性模型进行分析,对相关协变量如年龄进行调整,性别,教育,疑似与确诊的COVID诊断,MDD诊断,和酒精消费。结果:在147名参与者中,143名参与者有可用的基线数据进行分析。我们观察到基线PCFS评分与基线SHAPS评分呈统计学显著正相关(β=0.070,p=0.045,95%CI)。讨论:我们的分析显示,患有PCC的成年人的快感缺失程度与社会心理功能之间存在显着关系。旨在改善PCC患者报告结果的策略需要优先考虑预防和治疗PCC患者的享乐主义障碍。
UNASSIGNED: Post-COVID-19 condition (PCC), also known as \"long COVID,\" is characterized by persistent symptoms, negatively affecting the well-being of individuals with PCC.
Anhedonia (i.e. reduced capacity for pleasure) and compromised psychosocial functioning are notable symptoms in those with PCC. We aimed to provide insights to understand the effects of
anhedonia and impaired psychosocial functioning of individuals with PCC.
UNASSIGNED: This post-hoc analysis used data from an 8-week, double-blind, randomized, placebo-controlled trial which evaluated vortioxetine for cognitive deficits in individuals with PCC (Clinicaltrials.gov Identifier: NCT05047952). A total of 147 eligible participants were randomly assigned to receive vortioxetine or matching placebo over eight weeks of double-blind treatment. Our study investigated the relationship between
anhedonia, assessed by the Snaith-Hamilton Pleasure Scale (SHAPS), and psychosocial functioning, measured with the Post-COVID Functional Status (PCFS) scale. The analysis was conducted using a generalized linear model, with adjustments for relevant covariates such as age, sex, education, suspected versus confirmed COVID diagnosis, MDD diagnosis, and alcohol consumption.
UNASSIGNED: Of the 147 participants, 143 participants had available baseline data for analysis. We observed that baseline PCFS score was statistically significantly positively correlated to baseline SHAPS score (β = 0.070, p = 0.045, 95% CI).
UNASSIGNED: Our analysis revealed a significant relationship between measures of
anhedonia and psychosocial functioning in adults with PCC. Strategies that aim to improve patient-reported outcomes with PCC need to prioritize the prevention and treatment of hedonic disturbances in patients experiencing PCC.