成釉细胞纤维肉瘤(AFS)是一种罕见的颌骨恶性牙源性肿瘤。AFS的特征是由良性牙源性上皮和恶性间质成分组成。下颌骨的后部区域是主要的占据部位。在本报告中,我们描述了1例新的AFS病例,该病例发生在一名22岁男性中,该病例起源于成釉细胞性纤维瘤.组织学上,肿瘤显示双相成分:良性上皮和恶性间质成分。免疫化学结果显示,肿瘤细胞对分化簇(CD)34,波形蛋白,Ki-67和p53,但平滑肌肌动蛋白阴性,S-100,CD68和desmin。临床表现,我们还对影像学表现和治疗措施进行了描述和回顾.
Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic neoplasm of the jaw. AFS is characteristically composed of a benign odontogenic epithelium and a malignant mesenchymal component. The posterior region of the mandible is the predominantly occupied site. In the present report, a new case of AFS in a 22-year-old male that originated from ameloblastic fibroma was described. Histologically, the tumor showed biphasic components: Benign epithelium and a malignant mesenchymal component. Immunochemical findings revealed that the tumor cells were positive for cluster of differentiation (CD) 34, vimentin, Ki-67 and p53, but negative for smooth muscle actin, S-100, CD68 and desmin. The clinical presentation, radiographic appearances and treatment measures were additionally described and reviewed.