■神经母细胞瘤是一种恶性程度高,转移风险高的实体恶性肿瘤。神经母细胞瘤的预后范围从自发消退到对治疗不敏感和广泛转移。有一种非侵入性的,全景成像技术称为18F-氟代脱氧葡萄糖(18F-FDG)正电子发射断层扫描-计算机断层扫描(PET/CT),通过CT可以提供完整的解剖信息,并通过正电子发射检测可以提供肿瘤中FDG摄取值的程度。PET/CT是评估肿瘤代谢活动的一种有效方法,和PET/CT参数已被证明与各种肿瘤的预后有关。然而,PET/CT对神经母细胞瘤预后的预测表现尚不清楚.这项荟萃分析旨在评估最大标准化摄取值(SUVmax)的预测值,代谢性肿瘤体积(MTV),和无进展生存期(PFS)的总病变糖酵解(TLG),无事件生存(EFS),神经母细胞瘤患者的总生存期(OS)。
■PubMed中的文献,Embase,科克伦图书馆,从1985年1月至2023年6月,搜索了WebofScience,以评估PET/CT参数对神经母细胞瘤预后的预测价值。搜索项目主要包括“正电子发射断层扫描计算机断层扫描”和“神经母细胞瘤”。使用危险比(HR)作为汇总统计数据来评估SUVmax的关联,MTV,和带PFS的TLG,EFS,神经母细胞瘤患者的OS。进行异质性检验和敏感性分析。
■纳入了8项研究,有325名参与者。Meta分析显示较高的SUVmax与较短的OS相关[HR=1.27,95%CI(1.11,1.45),p=0.001],而与PFS无关[HR=1.03,95%CI(0.99,1.07),p=0.222]和EFS[HR=2.58,95%CI(0.37,18.24),提出了p=0.341]。MTV与OS无相关性[HR=2.46,95%CI(0.34,18.06),p=0.376]和PFS[HR=2.60,95%CI(0.68,9.88),p=0.161]。TLG和OS之间存在统计学上的显著关联[HR=1.00,95%CI(1.00,1.00),p=0.00],虽然HR是1,所以不能得出结论,TLG与PFS无相关性[HR=1.00,95%CI(0.99,1.00),p=0.974]。
■高SUVmax表明神经母细胞瘤患者的OS较差。MTV和TLG是潜在的预后预测因子,需要通过更精心设计的研究进一步验证。
■https://www.crd.约克。AC.英国/PROSPERO/,标识符340729。
UNASSIGNED: Neuroblastoma is a solid malignant tumor with high malignancy and high risk for metastasis. The prognosis of neuroblastoma ranges from spontaneous regression to insensitivity to therapies and widespread metastasis. There is a non-invasive, panoramic imaging technique called 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET/CT), which can provide both complete anatomical information via CT and extent of FDG uptake value in tumors via positron emission detection. PET/CT is a powerful approach to estimating tumoral metabolic activities, and PET/CT parameters have been demonstrated to be associated with the prognosis of various tumors. However, the predictive performance of PET/CT for the prognosis of neuroblastoma remains unclear. This meta-analysis aims to assess the predictive values of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) for progression-free survival (PFS), event-free survival (EFS), and overall survival (OS) in neuroblastoma patients.
UNASSIGNED: Literature in PubMed, Embase, Cochrane Library, and Web of Science from January 1985 to June 2023 was searched for studies evaluating predictive values of PET/CT parameters for the prognosis of neuroblastoma. Search items mainly included \"Positron Emission Tomography Computed Tomography\" and \"Neuroblastoma\". Hazard ratio (HR) was used as a pooled statistic to assess the association of SUVmax, MTV, and TLG with PFS, EFS, and OS in neuroblastoma patients. Heterogeneity test and sensitivity analysis were performed.
UNASSIGNED: There were eight studies included, with 325 participants. Meta-analysis showed that higher SUVmax was associated with shorter OS [HR = 1.27, 95% CI (1.11, 1.45), p = 0.001], while no association with PFS [HR = 1.03, 95% CI (0.99, 1.07), p = 0.222] and EFS [HR = 2.58, 95% CI (0.37, 18.24), p = 0.341] was presented. MTV showed no association with OS [HR = 2.46, 95% CI (0.34, 18.06), p = 0.376] and PFS [HR = 2.60, 95% CI (0.68, 9.88), p = 0.161]. There was a statistically significant association between TLG and OS [HR = 1.00, 95% CI (1.00, 1.00), p = 0.00], while the HR was 1, so the association could not be concluded, and TLG showed no association with PFS [HR = 1.00, 95% CI (0.99, 1.00), p = 0.974].
UNASSIGNED: High SUVmax indicates poor OS in patients with neuroblastoma. The MTV and TLG are potential prognostic predictors that need to be further validated by more well-designed studies.
UNASSIGNED: https://www.crd.york.ac.uk/PROSPERO/, identifier 340729.