脑血流量(CBF)的减少在肥胖的认知障碍和痴呆中起着至关重要的作用。然而,目前关于肥胖患者CBF变化的结论不一致.
进行了系统评价和荟萃分析,以评估肥胖与CBF改变之间的关系。
我们系统地筛选了发表的横断面和纵向研究,重点是肥胖和正常体重个体的CBF差异。18项研究,包括24,866名参与者,其中七篇文章报道了纵向结果,在本研究中进行了评估。
荟萃分析的结果表明,在横断面研究中,体重指数(BMI)与CBF呈负相关(β=-0.31,95%置信区间[CI]:-0.44,-0.19)。此外,这项系统评价表明,肥胖个体在额叶的不同功能区表现出CBF的全球和区域减少和CBF增加。包括前额叶皮层,左额上眶,右额叶眶中皮质,和左运动前额上回。
我们的研究结果表明BMI,而不是腰围和腰臀比,在横断面研究中与CBF呈负相关。肥胖个体的CBF显示出全球和地区的减少,包括额叶,颞叶和顶叶,小脑,海马体,还有丘脑.
Reduction in cerebral blood flow (CBF) plays an essential role in the cognitive impairment and dementia in obesity. However, current conclusions regarding CBF changes in patients with obesity are inconsistent.
A systematic
review and meta-analysis was performed to evaluate the relationship between obesity and CBF alterations.
We systematically screened published cross-sectional and longitudinal studies focusing on the differences in CBF between obese and normal-weight individuals. Eighteen studies including 24,866 participants, of which seven articles reported longitudinal results, were evaluated in the present study.
The results of the meta-analysis showed that in cross-sectional studies, body mass index (BMI) was negatively associated with CBF (β= -0.31, 95% confidence interval [CI]: -0.44, -0.19). Moreover, this systematic
review demonstrated that obese individuals showed global and regional reductions in the CBF and increased CBF in diverse functional areas of the frontal lobe, including the prefrontal cortex, left frontal superior orbital, right frontal mid-orbital cortex, and left premotor superior frontal gyrus.
Our findings suggest that BMI, rather than waist circumference and waist-to-hip ratio, is inversely associated with CBF in cross-sectional studies. The CBF of obese individuals showed global and regional reductions, including the frontal lobe, temporal and parietal lobes, cerebellum, hippocampus, and thalamus.