未经证实:镰状细胞病是一种遗传性疾病,常伴有血管闭塞危象(VOC)。卡塔尔大多数镰状细胞病患者是穆斯林;因此,他们在斋月期间实行间歇性禁食。然而,缺乏描述间歇性禁食对严重VOC发生的影响的文献。因此,缺乏指南或标准化方案,可以帮助医生建议希望间歇性禁食的镰状细胞病患者.因此,本研究的目的是探讨间歇性禁食对镰状细胞病患者临床和血液学参数的影响。
UNASSIGNED:我们对卡塔尔52名年龄≥18岁的镰状细胞病穆斯林患者进行了一项回顾性研究,这些患者在2019-2021年的斋月期间被确认为禁食。严重VOC发生的差异,溶血危象,和其他临床,血液学,和代谢参数在一个月前进行了研究,during,并在斋月间歇性禁食一个月后使用患者的医疗记录。平均值(SD),中位数(IQR),和频率(%)描述了数据。在0.05的α水平下使用具有Greenhouse-Geisser校正的单向重复测量ANOVA和Friedman检验(*)。
未经评估:研究参与者的(平均±sd)年龄为(31.1±9.2)岁,51.9%是男性,女性占48.1%。大约百分之七十的参与者是阿拉伯种族,其余的要么是非洲人,要么是亚洲人。大多数患者是纯合子(SS)(90.4%)。严重VOC(P=0.7)和溶血危象(P=0.5)的中位数没有发现明显差异。during,或斋月之后.显著差异,然而,在血小板计数中发现(P=0.003),网织红细胞计数(P<0.001),和肌酐水平(P=0.038)与间歇性禁食。
未经授权:在本初步研究中,间歇性禁食似乎并不影响镰状细胞病患者严重血管闭塞危象或溶血性危象的发生率;然而,发现它与血小板计数的差异有关,网织红细胞计数,和肌酐水平。这些发现的统计学和临床意义需要在样本量较大的研究中得到证实。
UNASSIGNED: Sickle cell disease is a genetic disorder that frequently presents with vaso-occlusive crisis (VOC). Most patients with sickle cell disease in Qatar are Muslims; hence, they practice intermittent fasting during the holy month of Ramadan. However, there is a paucity of literature describing the effect of intermittent fasting on the occurrence of severe VOC. As a result, there is a lack of guidelines or standardized protocols that can help physicians advise patients with sickle cell disease who wish to practice intermittent fasting. Therefore, this
study\'s aim was to investigate the effect of intermittent fasting on the clinical and hematological parameters of individuals with sickle cell disease.
UNASSIGNED: We conducted a retrospective
study for 52 Muslim patients with sickle cell disease in Qatar aged ≥18 years who were confirmed to be fasting during the holy month of Ramadan during any of the years 2019-2021. The difference in the occurrence of severe VOC, hemolytic crisis, and other clinical, hematological, and metabolic parameters were studied one month before, during, and one month after the intermittent fasting of Ramadan using the patient\'s medical records. Mean (sd), median (IQR), and frequency (%) described the data. One-way with repeated measures ANOVA with a Greenhouse-Geisser correction and Friedman tests (*) were used at alpha level 0.05.
UNASSIGNED: The
study participants\' (mean±sd) age was (31.1±9.2) years, 51.9% were males, and 48.1% were females. Roughly seventy percent of the participants were of Arab ethnicity, while the rest were either African or Asian. Most of the patients were homozygotes (SS) (90.4%). The median number of severe VOC (P = 0.7) and hemolytic crisis (P = 0.5) was not found to be significantly different before, during, or after Ramadan. Significant differences, however, were found in platelet count (P = 0.003), reticulocyte count (P < 0.001), and creatinine level (P = 0.038) with intermittent fasting.
UNASSIGNED: In this preliminary
study, intermittent fasting does not seem to influence the rate of occurrence of severe vaso-occlusive crisis or hemolytic crisis in patients with sickle cell disease; however, it was found to be associated with differences in platelet count, reticulocytes count, and creatinine level. The statistical and clinical significance of these findings needs to be confirmed in studies with a larger sample size.