PDF(Pubmed)
Abstract：
OBJECTIVE: Hypoxia is a known feature of sickle cell anaemia (SCA) which results from chronic anaemia and recurrent vaso-occlusive crisis (VOC) which can cause tissue ischaemia that leads to an end organ damage. The hallmark of SCA is chronic anaemia and recurrent vaso-occlusive crisis. The aim of this study is to compare the oxygen saturation of sickle cell anaemic individuals with the normal haemoglobin type (Hb AA) control and also to determine the prevalence of hypoxemia among SCA.
RESULTS: Two-hundred and twenty-two (136 Hb SS and 86 Hb AA) participated in the study. The mean ± SD of age (years), oxygen saturation (%) and pulse rate (bpm) of participants with sickle cell anaemia and Hb AA control were 21.85 ± 3.04 and 22.14 ± 3.18 (t = 0.701, p = 0.436), 95.21 ± 3.02 and 98.07 ± 0.81 (t=-8.598, p < 0.0001) and 77.10 ± 9.28 and 73.16 ± 8.52 (t = 3.173, p = 0.002) respectively. The prevalence of hypoxemia among SCA participants was 47.1%. Prevalence of hypoxemia in males with SCA was 60.9% while 39.1% of the females had hypoxemia.
RESULTS: Two-hundred and twenty-two (136 Hb SS and 86 Hb AA) participated in the study. The mean ± SD of age (years), oxygen saturation (%) and pulse rate (bpm) of participants with sickle cell anaemia and Hb AA control were 21.85 ± 3.04 and 22.14 ± 3.18 (t = 0.701, p = 0.436), 95.21 ± 3.02 and 98.07 ± 0.81 (t=-8.598, p < 0.0001) and 77.10 ± 9.28 and 73.16 ± 8.52 (t = 3.173, p = 0.002) respectively. The prevalence of hypoxemia among SCA participants was 47.1%. Prevalence of hypoxemia in males with SCA was 60.9% while 39.1% of the females had hypoxemia.
摘要：
目的：缺氧是镰状细胞性贫血（SCA）的一个已知特征，它是由慢性贫血和复发性血管闭塞性危象（VOC）引起的，可引起组织缺血，从而导致终末器官损伤。SCA的标志是慢性贫血和复发性血管闭塞危象。这项研究的目的是比较镰状细胞贫血个体与正常血红蛋白型（HbAA）对照的氧饱和度，并确定SCA中低氧血症的患病率。
结果：二百零二十二名（136HbSS和86HbAA）参与了这项研究。年龄的平均值±SD（岁），镰状细胞贫血和HbAA对照参与者的氧饱和度（％）和脉搏率（bpm）分别为21.85±3.04和22.14±3.18（t=0.701，p=0.436），分别为95.21±3.02和98.07±0.81(t=-8.598,p<0.0001)和77.10±9.28和73.16±8.52(t=3.173,p=0.002)。SCA参与者中低氧血症的患病率为47.1％。SCA男性低氧血症发生率为60.9%，女性低氧血症发生率为39.1%。
结果：二百零二十二名（136HbSS和86HbAA）参与了这项研究。年龄的平均值±SD（岁），镰状细胞贫血和HbAA对照参与者的氧饱和度（％）和脉搏率（bpm）分别为21.85±3.04和22.14±3.18（t=0.701，p=0.436），分别为95.21±3.02和98.07±0.81(t=-8.598,p<0.0001)和77.10±9.28和73.16±8.52(t=3.173,p=0.002)。SCA参与者中低氧血症的患病率为47.1％。SCA男性低氧血症发生率为60.9%，女性低氧血症发生率为39.1%。
