■贫血是大多数慢性疾病的常见合并症,但在2型糖尿病(T2DM)患者中没有得到很好的监测。在这项研究中,我们调查了加纳Ashanti地区医疗机构中2型糖尿病患者贫血的患病率及其与铁储存的关系.
这项多中心横断面研究招募了在库马西南医院和圣迈克尔斯医院的糖尿病诊所就诊的213名T2DM门诊患者,JachiePramso,加纳,进行例行检查。自我报告的问卷被用来收集社会人口统计学,生活方式,和研究参与者的临床数据。收集血样以估计血液学参数和铁储存。Mann-WhitneyU检验用于评估贫血和非贫血患者之间血液学参数和铁储存的差异。所有p<0.05被认为是统计学上显著的。
■在213名T2DM参与者中,贫血的患病率为31.9%。登记的女性145人(68.1%)多于男性68人(31.9%)。贫血患者的平均细胞体积水平显着降低[79.30/fLvs.82.60/fL,p=0.001],平均细胞血红蛋白[26.60/pgvs.27.90/pg,p<0.0001],和平均细胞血红蛋白浓度[33.10/g/dL)与33.80/g/dL,p<0.0001]比无贫血者。血清铁蛋白水平(p=0.1140),转铁蛋白(p=0.5070),铁(p=0.7950),和总铁结合能力(p=0.4610)在有或没有贫血的T2DM患者之间没有显着差异。
■尽管在我们的队列中T2DM患者贫血的患病率很高,患者呈现明显正常的铁储存。必须在T2DM患者中经常监测这种未识别的轻度贫血。
UNASSIGNED: Anemia has been a common comorbidity in most chronic diseases, but has not been well monitored in type 2 diabetes mellitus (T2DM) patients. In this
study, we investigated the prevalence of anemia and its nexus with iron stores among T2DM patients in health facilities in the Ashanti Region of Ghana.
UNASSIGNED: This multicenter cross-sectional
study recruited 213 T2DM out-patients attending the diabetic clinics at the Kumasi South Hospital and St. Michaels Hospital, Jachie Pramso, Ghana, for routine check-ups. Self-reported questionnaires were used to collect sociodemographic, lifestyle, and clinical data from
study participants. Blood samples were collected to estimate hematological parameters and iron stores. Mann-Whitney U test was used to assess the difference in hematological parameters and iron stores between anemic and nonanemic patients. All p < 0.05 were considered statistically significant.
UNASSIGNED: Of the 213 T2DM participants, the prevalence of anemia was 31.9%. More females 145 (68.1%) were registered than males 68 (31.9%). Anemic patients had significantly lower levels of mean cell volume [79.30/fL vs. 82.60/fL, p = 0.001], mean cell hemoglobin [26.60/pg vs. 27.90/pg, p < 0.0001], and mean cell hemoglobin concentration [33.10/g/dL) vs. 33.80/g/dL, p < 0.0001] than those without anemia. Serum levels of ferritin (p = 0.1140), transferrin (p = 0.5070), iron (p = 0.7950), and total iron binding capacity (p = 0.4610) did not differ significantly between T2DM patients with or without anemia.
UNASSIGNED: Despite the high prevalence of anemia among the T2DM patients in our cohort, patients present with apparently normal iron stores. This unrecognized mild anemia must be frequently monitored among T2DM patients.