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Abstract：
The aim of this study was to investigate the relationship between serum ferritin level and antioxidative status and metabolic dysregulation in young adult obese population. This cross-sectional study included 300 subjects of either sex, grouped as obese and non-obese subjects. The body mass index, total iron binding capacity, fasting blood glucose, superoxide dismutase activity, and levels of serum ferritin, iron, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, glutathione, and vitamin C were estimated. Analysis showed a significant alteration in all the parameters in obese adults. The correlation of ferritin level and body mass index showed a positive correlation (r = -0.81, p < 0.001, respectively) with levels of fasting blood glucose, superoxide dismutase, total cholesterol, low-density lipoprotein cholesterol, and triglyceride in obese individuals, whereas an insignificant correlation with vitamin C and glutathione level was observed in obese individuals. The significant positive correlation of ferritin level with the metabolic parameters and some antioxidative parameters in obese individuals signifies the development of metabolic disorders. Therefore, estimation of serum ferritin level will be an important early indicator for the risk of developing metabolic disorders in young adults.
摘要：
这项研究的目的是研究年轻成年肥胖人群中血清铁蛋白水平与抗氧化状态和代谢失调之间的关系。这项横断面研究包括300名男女受试者，分为肥胖和非肥胖受试者。体重指数,总铁结合能力，空腹血糖,超氧化物歧化酶活性，血清铁蛋白水平,铁,总胆固醇,高密度脂蛋白胆固醇，低密度脂蛋白胆固醇，甘油三酯，谷胱甘肽,和维生素C估计。分析显示，肥胖成年人的所有参数都发生了显着变化。铁蛋白、体重指数与空腹血糖呈正相关(r=-0.81,p<0.001),超氧化物歧化酶,总胆固醇,低密度脂蛋白胆固醇，肥胖个体的甘油三酯，而在肥胖个体中观察到与维生素C和谷胱甘肽水平无关。肥胖个体中铁蛋白水平与代谢参数和某些抗氧化参数的显着正相关表明代谢紊乱的发展。因此,血清铁蛋白水平的估计将是年轻人发生代谢紊乱风险的重要早期指标。
