围产期组织,如胎盘和脐带含有多种体干细胞类型,从大量使用的造血干细胞和祖细胞到最近描述的广泛的多能上皮细胞和基质细胞。作为围产期衍生物(PnD),其中几种细胞类型和相关产品为各种疾病提供了有趣的再生潜力。在COSTSPRINT行动中,我们继续我们的审查系列,修改和总结使用PnD产品的行动模式和拟议的医疗方法:细胞,分泌组,细胞外囊泡,和去细胞化的组织。专注于大脑,骨头,骨骼肌,心,肠,肝脏,和肺部病变,我们讨论了效力测试在验证PnD疗法中的重要性,并严格评估PnD在组织再生领域的应用概念。因此,我们旨在阐明PnD的实际治疗特性,对未来的临床应用持开放态度。这篇综述是用于验证PnD的功能/效力测定的四分法系列的一部分,跨越生物功能,如免疫调节,抗微生物/抗癌,抗炎,伤口愈合,血管生成,和再生。
Perinatal tissues, such as placenta and umbilical cord contain a variety of somatic stem cell types, spanning from the largely used hematopoietic stem and progenitor cells to the most recently described broadly multipotent epithelial and stromal cells. As perinatal derivatives (PnD), several of these cell types and related products provide an interesting regenerative potential for a variety of diseases. Within COST SPRINT Action, we continue our review series, revising and summarizing the modalities of action and proposed medical approaches using PnD products: cells, secretome, extracellular vesicles, and decellularized tissues. Focusing on the brain, bone, skeletal muscle, heart, intestinal, liver, and lung pathologies, we discuss the importance of potency testing in validating PnD therapeutics, and critically evaluate the concept of PnD application in the field of tissue regeneration. Hereby we aim to shed light on the actual therapeutic properties of PnD, with an open eye for future clinical application. This review is part of a quadrinomial series on functional/potency assays for validation of PnD, spanning biological functions, such as immunomodulation, anti-microbial/anti-cancer, anti-inflammation, wound healing, angiogenesis, and regeneration.