■低分化甲状腺癌是一种罕见的异质性恶性肿瘤,占所有甲状腺肿瘤的2-4%。胸骨下甲状腺肿(SG)定义为位于胸入口下方的甲状腺肿大。仅在2-3%的病例中报告了由SG引起的恶性肿瘤。该病例报告已根据外科护理报告(SCARE)标准报告。21。
本文介绍了一名54岁的叙利亚女性,她因吞咽困难而出现在我们的机构,呼吸困难,宫颈肿胀,和食欲不振。在临床和放射学检查之后,行甲状腺全切除术伴淋巴结清扫术。显微镜检查显示出岛状的浸润生长模式,小梁,和缺乏嗜酸性粒细胞的细胞质的上皮细胞的固体形成,超色核,和坏死区域的奇异有丝分裂图。随后,最终诊断为由SG引起的多灶性低分化甲状腺癌.
■低分化甲状腺癌的组织学特征的异质性代表了诊断挑战。低分化甲状腺癌的诊断基于都灵标准,突出了组织病理学特征。计算机断层扫描在SG的进一步评估中起着重要作用。
■在这份手稿中,作者旨在提供一个独特的病例报告,其具有挑战性的诊断特征,包括从SG快速发展为浸润性低分化甲状腺癌,强调在没有重要病史的情况下对甲状腺结节进行详细的组织病理学检查的重要性.
UNASSIGNED: Poorly differentiated thyroid carcinomas represent a rare heterogeneous group of malignant tumors that constitute ~2-4% of all thyroid neoplasms. Substernal goiter (SG) is defined as an enlargement of the thyroid gland that is located below the thoracic inlet. Malignant neoplasms arising from a SG were reported in only 2-3% of cases.This
case report has been reported in line with the Surgical
CAse REport (SCARE) Criteria.21.
UNASSIGNED: This article presents a 54-year-old Syrian female who presented at our institution due to dysphagia, dyspnea, cervical swelling, and loss of appetite. Following clinical and radiological examinations, total thyroidectomy with lymph node dissection was performed. Microscopic examination revealed an infiltrative growth pattern of insular, trabecular, and solid formations of epithelial cells with scant eosinophilic cytoplasm, hyperchromatic nuclei, and bizarre mitotic figures with areas of necrosis. Subsequently, the final diagnosis was confirmed as a multifocal poorly differentiated thyroid carcinoma arising from a SG.
UNASSIGNED: The heterogeneity of histologic features of poorly differentiated thyroid carcinoma represents a diagnostic challenge. Diagnosis of poorly differentiated thyroid carcinomas is based on the Turin Criteria, which highlights histopathological features. Computed tomography plays a major role in SG for further evaluation.
UNASSIGNED: In this manuscript, the authors aimed to present a unique
case report with challenging diagnostic features including the rapid development of an infiltrative poorly differentiated thyroid carcinoma from a SG highlighting the importance of a detailed histopathological examination of thyroid nodules in the absence of significant medical history.