我们目前正在经历一种致命的新型病毒大流行,SARS-CoV-2的现成抗病毒疗法。病毒会劫持宿主细胞机器,包括代谢过程。这里,我为靶向宿主从头嘌呤合成途径提供了理论和证据,用于广谱抗病毒药物的开发以及追求基础科学,以减轻未来新型病毒爆发的风险。
We are currently experiencing a deadly novel viral pandemic with no efficacious, readily available anti-viral therapies to SARS-CoV-2. Viruses will hijack host cellular machinery, including metabolic processes. Here, I provide theory and evidence for targeting the host de novo purine synthetic pathway for broad spectrum anti-viral drug development as well as the pursuit of basic science to mitigate the risks of future novel viral outbreaks.