空心金纳米球(HGNs)是具有介电材料核心的核/壳结构,通常由溶剂组成,还有一个金金属外壳.这种结构具有两个金属/电介质界面以允许金金属与内部和外部电介质环境之间的相互作用。在光线照射下,与固体金纳米粒子相比,HGN表现出独特的表面等离子体共振(SPR)性质。它们的SPR吸收/散射可以通过改变它们的直径来调节,壳体厚度,和表面形态。除了低毒性,易于功能化,耐光漂白,以及对周围黄金介质变化的敏感性,HGNs的增强的表面体积比和可调的SPR使它们在传感领域的不同应用中极具吸引力,治疗,和theranostics。在这篇文章中,本文综述了近年来HGNs的合成和结构控制及其SPR特性在生物医学传感和治疗中的应用进展。本文分类如下:诊断工具>生物传感诊断工具>体外基于纳米颗粒的传感诊断工具>体内纳米诊断和成像。
Hollow gold nanospheres (HGNs) are core/shell structures with a dielectric material core, usually composed of solvent, and a gold metal shell. Such structures have two metal/dielectric interfaces to allow interaction between the gold metal with the interior and external dielectric environment. Upon illumination by light, HGNs exhibit unique surface plasmon resonance (SPR) properties compared to solid gold nanoparticles. Their SPR absorption/scattering can be tuned by changing their diameter, shell thicknesses, and surface morphologies. In addition to the low toxicity, easy functionalization, resistance to photobleaching, and sensitivity to changes in surrounding medium of gold, the enhanced surface-to-volume ratio and tunable SPR of HGNs make them highly attractive for different applications in the fields of sensing, therapy, and theranostics. In this article, we
review recent progress on the synthesis and structural control of HGNs and applications of their SPR properties in biomedical sensing and theranostics. This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > in vitro Nanoparticle-Based Sensing Diagnostic Tools > in vivo Nanodiagnostics and Imaging.