背景:这种前瞻性,病例系列研究旨在评估富含生长因子的血浆(PRGF)在慢性下腰痛(LBP)患者中的临床疗效,并确定应答患者的特征.材料与方法:将PRGF注射入椎间盘,32例慢性LBP患者的硬膜外腔和/或关节突和骶髂关节。3个月和6个月后通过算法功能评分评估治疗的疗效。结果:总体而言,患者在PRGF治疗后没有改善,尽管有8例患者表现出algo功能改善。他们主要是在两个较年轻的地点接受治疗的男性,与无反应者相比,久坐不动,肌肉骨骼合并症较少。结论:在患有慢性LBP的难以治疗患者的特定亚群中,PRGF是一种潜在的治疗方法。
简单的语言总结在这项研究中,32例慢性下腰痛(LBP)患者接受血浆富含生长因子(PRGF)治疗,以评估其临床疗效长达6个月。结果表明,分析整个队列,PRGF并未改善患者的病情.然而,八名患者对治疗的反应是表现出算法功能改善。他们主要是男性,小于50岁/年龄,积极的生活习惯,与没有反应的患者相比,肌肉骨骼合并症更少。当在一个椎间盘和相应水平的小关节处注射PRGF时,可获得最佳结果。总之,如果用于具有特定特征的患者,PRGF可能是一种有效的治疗方法。
Background: This prospective,
case-series study aimed to assess the clinical effectiveness of plasma rich in growth factors (PRGF) in patients with chronic low back pain (LBP) and to identify the features of the responsive patients. Materials & methods: PRGF was injected into the intervertebral disc, epidural space and/or facet and sacroiliac joints of 32 patients with chronic LBP. The efficacy of the treatment was assessed by algo-functional scores after 3 and 6 months. Results: Overall, the patients did not ameliorate after PRGF treatment, although eight patients showed an algo-functional improvement. They were mainly males treated at two sites who were younger, less sedentary and with fewer musculoskeletal co-morbidities than the nonresponders. Conclusion: PRGF is a potential treatment in a specific subpopulation of difficult-to-treat patients affected by chronic LBP.
Plain language summary In this study, 32 patients with chronic low back pain (LBP) were treated with plasma rich in growth factors (PRGF) to evaluate its clinical efficacy up to 6 months. The results showed that, analyzing the total cohort, the PRGF did not ameliorate the patients\' conditions. However, eight patients responded to the treatment by showing an algo-functional improvement. They were mainly males, younger than 50 years/old, with active lifestyle habits, and with less musculoskeletal co-morbidities than the patients who did not respond. Best results were obtained when PRGF was injected at one intervertebral disc plus facet joints at the corresponding level. In conclusion, PRGF may be an effective treatment if used in patients with specific characteristics.