弯曲杆菌病在世界范围内引起人类的重大疾病负担,并且是芬兰最常见的人畜共患胃肠炎。为了确定国内弯曲杆菌感染的感染源,我们分析了2004-2021年芬兰传染病注册中心(FIDR)的弯曲杆菌病例数据和2010-2021年国家食源性和水源性暴发疫情注册中心(FWO注册中心)的疫情数据,并于2022年7-8月进行了病例对照试验研究(256例病例和756例对照),并采用全基因组测序(WGS)进行来源归属和患者样本分析.在FIDR中,41%的病例缺乏旅行史信息。基于病例对照研究,我们估计在所有案件中,39%来自国内。使用WGS,在185例国内病例中观察到22组两个或两个以上病例,这些都没有报告到FWO登记册。基于本病例对照研究和来源归因,家禽是芬兰弯曲杆菌病的重要来源。对患者进行更广泛的采样和比较,食物,动物,和环境分离需要估计其他来源的重要性。在芬兰,弯曲杆菌病通常比FIDR通知显示的更多来自家庭。为了确定国内案件,旅行信息应包括在FIDR通知中,并改善爆发检测,所有国内患者分离株都应进行测序.
Campylobacteriosis causes a significant disease burden in humans worldwide and is the most common type of zoonotic gastroenteritis in Finland. To identify infection sources for domestic Campylobacter infections, we analyzed Campylobacter
case data from the Finnish Infectious Disease Register (FIDR) in 2004-2021 and outbreak data from the National Food- and Waterborne Outbreak Register (FWO Register) in 2010-2021, and conducted a pilot
case-control study (256 cases and 756 controls) with source attribution and patient sample analysis using whole-genome sequencing (WGS) in July-August 2022. In the FIDR, 41% of the cases lacked information on travel history. Based on the
case-control study, we estimated that of all cases, 39% were of domestic origin. Using WGS, 22 clusters of two or more cases were observed among 185 domestic cases, none of which were reported to the FWO register. Based on this
case-control study and source attribution, poultry is an important source of campylobacteriosis in Finland. More extensive sampling and comparison of patient, food, animal, and environmental isolates is needed to estimate the significance of other sources. In Finland, campylobacteriosis is more often of domestic origin than FIDR notifications indicate. To identify the domestic cases, travel information should be included in the FIDR notification, and to improve outbreak detection, all domestic patient isolates should be sequenced.