目的:对SNORA42在癌变中的作用进行系统的文献综述,以阐明其重要性,其作为生物标志物和治疗靶标的潜在用途。
方法:使用PubMed,SciELO和ScienceDirect数据库作为搜索手段,符合研究范围的文章,用英语写的,在2012年至2022年之间发表的文章,使用以下关键词选择:“小核仁RNA42”,\"snoRNA42\"和\"SNORA42\",以及搜索这个snoRNA的同义词(SNORA80E,方框H/ACA42和ACA42)。
结果:在总共131项研究中,七个被选中,其中可以确定SNORA42干扰了几种生物过程,如扩散,迁移,入侵,转移,凋亡,和信号通路。在信号通路中,p53和NF-KappaB通路突出。此外,它是诊断的潜在生物标志物,预后,和癌症的治疗。
结论:关于SNORA42在癌变和癌症进展过程中的主要信息的摘要表明,这种snoRNA的使用对于肿瘤学领域的未来应用是理想的,其中它可以用作生物标志物和治疗靶标。因此,开展新研究以巩固该分子的适用性至关重要。
OBJECTIVE: Perform a systematic literature
review on SNORA42 in carcinogenesis in order to elucidate its importance, its potential use as a biomarker and as a therapeutic target.
METHODS: Using PubMed, SciELO and Science Direct databases as search means, articles that are in line with the scope of the study, written in English, that were published between 2012 and 2022, were selected using the following keywords: \"small nucleolar RNA 42\", \"
snoRNA 42\" and \"SNORA42\", as well as searches for the synonyms of this
snoRNA (SNORA80E, box H/ACA 42 and ACA42).
RESULTS: From a total of 131 studies, seven were selected, in which it was possible to identify that SNORA42 interferes in several biological processes, such as proliferation, migration, invasion, metastasis, apoptosis, and signaling pathways. Among the signaling pathways, the p53 and NF-KappaB pathways stand out. Moreover, it is a potential biomarker for diagnosis, prognosis, and treatment of cancer.
CONCLUSIONS: The summary of the main information about SNORA42 in the process of carcinogenesis and cancer progression shows that the use of this
snoRNA is ideal for future applications in the field of oncology, in which it can be used as a biomarker and therapeutic target. Thus, it is of fundamental importance to carry out new studies to consolidate the applicability of this molecule.