背景:1型糖尿病孕妇的后代与无糖尿病妇女的后代相比,早发肥胖和2型糖尿病的风险更高。皮肤自发荧光(SAF)是累积的晚期糖基化终产物(AGEs)的标志,它已被证明可以预测2型糖尿病,心血管疾病,和普通人群的死亡率。这项研究的目的是评估母亲1型糖尿病是否会影响年轻成年后代的SAF值。
方法:这项横断面病例对照研究包括78名1型糖尿病女性的后代(病例)和85名对照参与者(对照)。所有研究参与者,18-23岁,被邀请参加临床评估,包括实验室测试和问卷调查。使用来自每个参与者的优势前臂的AGE阅读器评估SAF。
结果:病例(1.61[标准偏差(SD)0.37])任意单位[AU])和对照(1.64[SD0.41]AU)之间的平均SAF值没有差异(p=0.69)。糖化血红蛋白A1c调整后,身体脂肪百分比,吸烟,和季节平均SAF值在病例和对照组之间没有差异(p=0.49),但在男性和女性之间有差异(p=0.008),没有观察到任何相互作用(p=0.78)。
结论:SAF值在1型糖尿病女性的年轻成年后代和非糖尿病母亲所生的后代之间没有差异。令人惊讶的是,在病例组和对照组中,年轻成年女性的SAF值均高于男性.
BACKGROUND: Offspring born to women with type 1 diabetes pregnancies have an elevated risk for early-onset obesity and type 2 diabetes compared with offspring born to women without diabetes. Skin autofluorescence (SAF) is a marker of accumulated advanced glycation end products (AGEs) and it has been shown to predict type 2 diabetes, cardiovascular disease, and mortality in the general population. The aim of this study was to evaluate whether maternal type 1 diabetes influences the SAF value in young adult offspring.
METHODS: This cross-sectional
case-control study included 78 offspring of women with type 1 diabetes (cases) and 85 control participants (controls). All study participants, aged 18-23 years, were invited to participate in a clinical assessment including laboratory tests and questionnaires. SAF was assessed using the AGE reader from the dominant forearm of each participant.
RESULTS: The mean SAF value did not differ between the cases (1.61 [standard deviation (SD) 0.37]) arbitrary units [AU]) and the controls (1.64 [SD 0.41] AU) (p = 0.69). After adjusting for glycated hemoglobin A1c, body fat percentage, smoking, and season the mean SAF value did not differ between the cases and the controls (p = 0.49) but differed between men and women (p = 0.008), without any interaction observed (p = 0.78).
CONCLUSIONS: SAF values did not differ between the young adult offspring of women with type 1 diabetes and offspring born to mothers without diabetes. Surprisingly, young adult women showed higher SAF values than men in both
case and control groups.