■深部脑刺激(DBS)有效治疗帕金森的运动症状,但它对泌尿生殖系统的影响仍有争议。
■在PubMed进行了一项研究,Embase,科克伦图书馆,WebofScience,和Scopus,直到2024年2月27日。我们主要关注DBS对帕金森病患者尿液储存功能的影响,排泄功能,性功能,和生活质量。
■我们的荟萃分析包括14项研究。主要结果表明,就储尿功能而言,DBS减少了尿急(OR=1.85,95%CI:1.26至2.70,p=0.002),并增加了最大膀胱容量(MD=-66.10,95%CI:-119.37至-12.82,p=0.02)。然而,首次求空欲望和强烈求空欲望没有显著差异。在排尿功能方面,DBS显示最大流量显着改善(MD=-0.64,95%CI:-1.23至-0.05,p=0.03),后空隙残留(MD=-6.79,95%CI:4.54至9.05,P<0.00001)和最大流量期间逼尿肌压力(MD=-1.37,95%CI:-2.73至-0.02,p=0.05)。此外,两组性功能差异无统计学意义(MD=-1.41,95%CI:-12.40~9.57,p=0.80)。
■DBS在改善帕金森病患者的储尿和排尿功能方面具有一定程度的疗效。然而,某些尿动力学参数或评分未显示任何统计学差异.此外,DBS对男性帕金森病患者的勃起功能无明显影响。
■https://www.crd.约克。AC.uk/prospro/display_record.php?ID=CRD42023476661,标识符CRD42023476661。
UNASSIGNED: Deep Brain Stimulation (DBS) effectively treats Parkinson\'s motor symptoms, but its effects on the urogenital system are debated.
UNASSIGNED: A research was conducted in PubMed, Embase, Cochrane Library, Web of Science, and Scopus until February 27, 2024. We primarily focused on DBS\'s impact on Parkinson\'s patients\' Urine storage function, voiding function, sexual function, and quality of life.
UNASSIGNED: Our meta-analysis included 14 studies. The main results showed that DBS resulted in fewer instances of urinary urgency (OR = 1.85, 95% CI: 1.26 to 2.70, p = 0.002) and increased maximum bladder capacity (MD = -66.10, 95% CI: -119.37 to -12.82, p = 0.02) in terms of urinary storage function. However, there were no significant differences in first desire to void and strong desire to void. In terms of voiding function, DBS showed significant improvements in maximum flow rate (MD = -0.64, 95% CI: -1.23 to -0.05, p = 0.03), post-void residual (MD = -6.79, 95% CI: 4.54 to 9.05, P < 0.00001) and detrusor pressure during maximum flow (MD = -1.37, 95% CI: -2.73 to -0.02, p = 0.05). Additionally, there was no significant difference in sexual function between the two groups (MD = -1.41, 95% CI: -12.40 to 9.57, p = 0.80).
UNASSIGNED: DBS has demonstrated a certain degree of efficacy in ameliorating urinary storage and voiding function in patients with Parkinson\'s disease. However, certain urodynamic parameters or scores do not demonstrate any statistically significant disparities. Furthermore, DBS has no significant impact on erectile function in male Parkinson\'s patients.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023476661, identifier CRD42023476661.