Abstract：
Premature ovarian insufficiency (POI) is a rare condition characterized by loss of ovarian function before the age of 40. POI seems associated with mood disorders and sexual dysfunction. However, there is a lack of high-quality evidence relating to the impact of POI on sexual function. Therefore, we conducted a systematic review and meta-analysis to evaluate sexual function in women with POI compared to women without the condition. The following online databases were systematically searched up to January 2023: EMBASE, Medline (Ovid), Web of Science, Cochrane, PsychInfo, and Google Scholar. Random effects models were used for analyses, with data reported as Hedges\' g and 95 % confidence interval, and the risk of heterogeneity was evaluated. The protocol of this study was registered with PROSPERO (CRD42023437203). A total of 10 studies were included in the systematic review and 5 studies involving 352 women with POI were included in the meta-analysis. Eight of the ten studies concluded that women with POI have reduced sexual function. An overall medium Hedges\' g effect size of -0.72 was found (ranging between -0.20 and -1.29) in favor of control women, with moderate heterogeneity (I2 = 64 %). Stratified studies of women on systemic hormone replacement therapy (HRT) showed an even higher Hedges\' g effect size, of -0.82 (95 % CI -1.18, -0.47). In conclusion, sexual function in women with POI is reduced compared with control women. Sexual function should be discussed with women with POI and they should be offered psychosexual counseling.
摘要：
过早卵巢功能不全（POI）是一种罕见的疾病，其特征是40岁之前卵巢功能丧失。POI似乎与情绪障碍和性功能障碍有关。然而,缺乏关于POI对性功能影响的高质量证据.因此,我们进行了系统评价和荟萃分析,以评估患有POI的女性与没有患有POI的女性的性功能.截至2023年1月，对以下在线数据库进行了系统搜索：EMBASE，Medline(Ovid),WebofScience,科克伦,PsychInfo,谷歌学者。随机效应模型用于分析，数据报告为对冲和95%置信区间，并对异质性风险进行了评估。本研究的方案在PROSPERO(CRD42023437203)注册。共有10项研究纳入系统评价，5项研究纳入352名患有POI的女性。十项研究中有八项得出结论，患有POI的女性性功能降低。发现总体中等对冲效应大小为-0.72（范围在-0.20和-1.29之间）有利于对照女性，中度异质性（I2=64%）。对女性进行系统性激素替代疗法（HRT）的分层研究显示，对冲效应的大小甚至更高，为-0.82（95%CI-1.18，-0.47）。总之,与对照组女性相比，POI女性的性功能降低。应与患有POI的女性讨论性功能，并应向她们提供心理性咨询。
