目的:雄激素水平从成年早期开始下降,并且随着体重指数的增加,男性的下降幅度更大。是的,然而,不清楚在何种程度上,身体成分和代谢的其他指标的变化与健康男性的性类固醇水平的变化有关。因此,这项研究调查了健康成年男性身体成分和代谢健康与性类固醇水平的纵向变化。
方法:纵向,以人群为基础的研究。在基线和±12年后测量676名24-46岁的健康男性。
方法:使用免疫测定法测定血清性激素结合球蛋白(SHBG),睾酮(T),雌二醇(E2),使用LC-MS/MS的双氢睾酮,计算游离T和E2(cFE2)以及胰岛素抵抗的稳态模型(HOMA-IR)。通过手握力测量法测量握力。使用双能X射线吸收法和外周定量计算机断层扫描确定身体成分。
结果:平均脂肪量(FM),瘦体重(LM)和HOMA-IR增加(所有p<0.001)。雄激素和SHBG水平降低与FM升高有关,而降低(cF)E2水平与降低FM相关(所有p<0.005)。降低(cF)E2水平和增加SHBG水平与降低LM相关(所有p<0.002)。性类固醇水平的变化与HOMA-IR或握力无关。
结论:衰老导致脂肪质量指数和胰岛素抵抗增加,而瘦体重参数的变化不太明确。在健康的成年男性中,性类固醇暴露的生理变化与肥胖的变化明显相关,但与瘦体重无关。胰岛素抵抗或握力。
OBJECTIVE: Androgen levels decline from early adulthood and decreases are steeper in men with increasing body mass index. It is, however, unclear to what extent changes in other indices of body composition and metabolism associate with changes in sex steroid levels in healthy men. Therefore, this
study investigated longitudinal changes in body composition and metabolic health in relation to sex steroid levels in healthy adult men.
METHODS: This is a longitudinal, population-based
study. A total of 676 healthy men aged 24-46 years were measured at baseline and after ±12 years.
METHODS: Serum sex hormone-binding globulin (SHBG) was measured by immunoassay, testosterone (T), estradiol (E2), and dihydrotestosterone byliquid chromatography with tandem mass spectrometry (LC-MS/MS), calculated free T and calculated free E2 (cFE2), and homeostasis model assessment for insulin resistance (HOMA-IR) were calculated. Grip strength was measured by hand-grip dynamometry. Body composition was determined using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography.
RESULTS: Mean fat mass (FM), lean mass (LM), and HOMA-IR increased (all P < .001). Decreasing androgen and SHBG levels was associated with increasing FM, whereas decreasing (cF)E2 levels were associated with decreasing FM (all P < .005). Decreasing (cF)E2 levels and increasing SHBG levels associated with decreasing LM (all P < .002). Changes in sex steroid levels and HOMA-IR or grip strength were not interrelated.
CONCLUSIONS: Aging leads to increases in FM indices and insulin resistance, whereas changes in parameters of LM are less unequivocal. In healthy adult men, physiological changes in sex steroid exposure clearly correlate with changes in adiposity but not so with lean mass, insulin resistance, or grip strength.
BACKGROUND: The SIBEX
study was registered on ClinicalTrials.gov (#NVT02997033).