■孤立的胎儿脑室增宽会产生一系列后果,从轻度神经发育延迟到围产期死亡;这些后果的程度通常取决于脑室增宽的严重程度。本系统评价和荟萃分析旨在研究从妊娠第15周开始诊断为孤立性胎儿脑室肥大的胎儿中,心室扩张程度对神经发育延迟和不良围产期结局风险的影响。
■PubMed,Embase,以电子方式搜索Scopus和Cochrane图书馆,以确定调查轻度和/或重度孤立胎儿脑室增宽预后的研究。如果他们报告了从妊娠15周及以后的产前诊断为孤立的胎儿脑室增宽的胎儿的神经发育或围产期结局,则纳入文章。如果研究报告了非孤立性脑室增宽(IVM),则将其排除在外,没有说明脑室增宽的程度,是非英语论文,动物研究或在21年的兴趣期之外发表。研究质量由两名独立评审员使用改良版本的纽卡斯尔-渥太华质量评估量表进行评估。当心室直径测量为10-15或>15mm时,将心室肥大定义为轻度或重度,分别。对不良神经发育结局进行了荟萃分析,胎儿宫内死亡和婴儿死亡。
■删除重复项之后,搜索产生了2452次引用,其中23项研究纳入,8项符合meta分析的条件.轻度和重度孤立性胎儿脑室增宽767例和347例,分别。在严重病例中,不良结果的发生率始终高于轻度病例。不良神经发育结果的相对风险,胎儿宫内死亡和婴儿死亡率为4.24[95%置信区间(CI):2.46-7.30],4.46(95%CI:1.64-12.11)和6.02(95%CI:1.73-21.00),分别,比较轻度和重度孤立的胎儿脑室增宽病例。
■不良神经发育和围产期结局的可能性,包括宫内和婴儿死亡率,与轻度孤立的胎儿脑室增宽相比,严重孤立的胎儿脑室增宽增加。
UNASSIGNED: Isolated fetal ventriculomegaly can have a range of consequences, ranging from mild neurodevelopmental delay to perinatal death; the extent of these consequences often depend on the severity of ventriculomegaly. This systematic
review and meta-analysis aims to investigate the impact of the degree of ventricular dilatation on the risk of neurodevelopmental delay and adverse perinatal outcomes in fetuses diagnosed with isolated fetal ventriculomegaly from gestational week 15 onwards.
UNASSIGNED: PubMed, Embase, Scopus and the Cochrane Library were searched electronically to identify studies investigating the prognosis of mild and/or severe isolated fetal ventriculomegaly. Articles were included if they reported neurodevelopmental or perinatal outcomes in fetuses prenatally diagnosed with isolated fetal ventriculomegaly from week 15 of gestation and onwards. Studies were excluded if they reported on non-isolated ventriculomegaly (IVM), failed to specify the degree of ventriculomegaly, were non-English papers, animal studies or published outside of the 21-year period of interest. Study quality was assessed by two independent reviewers using a modified version of the Newcastle-Ottawa Quality Assessment Scale. Ventriculomegaly was defined as either mild or severe when ventricular diameter measured as 10-15 or >15 mm, respectively. Meta-analyses were conducted for adverse neurodevelopmental outcome, intrauterine fetal demise and infant mortality.
UNASSIGNED: Following the removal of duplicates, the search yielded 2,452 citations, of which 23 studies were included and 8 were eligible for meta-analysis. There were 767 and 347 cases of mild and severe isolated fetal ventriculomegaly, respectively. Adverse outcomes were consistently reported at a higher rate in severe cases than mild. The relative risks of adverse neurodevelopmental outcome, intrauterine fetal demise and infant mortality were 4.24 [95% confidence interval (CI): 2.46-7.30], 4.46 (95% CI: 1.64-12.11) and 6.02 (95% CI: 1.73-21.00), respectively, upon comparison of mild versus severe cases of isolated fetal ventriculomegaly.
UNASSIGNED: The likelihood of adverse neurodevelopmental and perinatal outcomes, including intrauterine and infant mortality, is increased in severe isolated fetal ventriculomegaly compared to mild isolated fetal ventriculomegaly.