背景:超声心动图应变成像的心肌变形是心脏病学中的关键测量,提供有价值的诊断和预后信息。应从大量健康人群中建立菌株的参考范围,并具有最小的方法学偏差和变异性。
目的:本研究的目的是建立超声心动图参考范围,包括所有4个心腔的整体应变的正常下限,通过来自大量健康人群的指南指导的专门观点,并评估受试者特定特征对菌株的影响。
方法:总共,来自HUNT4Echo的1,329名健康参与者,Trøndelag健康研究第四波的超声心动图子研究,包括在内。根据当前的建议,对每个腔室的特定超声心动图记录进行了优化。两名经验丰富的超声医师使用GEHealthCareVividE95扫描仪记录了所有超声心动图。由专家使用GEHealthCareEchoPAC进行分析。
结果:左心室(LV)整体纵向应变和右心室游离壁应变的参考范围为-24%至-16%和-35%至-17%,分别。相应地,左心房(LA)和右心房(RA)储层应变分别为17%至49%和17%至59%。随着年龄的增长,所有菌株的绝对值都较低,除了LA和RA收缩应变,更高。菌株的可行性总体良好(LV96%,右心室83%,洛杉矶94%,和RA87%)。所有腔室特异性菌株都与年龄有关,LV菌株与性别有关。
结论:所有心腔的应变参考范围是基于指南指导的腔室特异性记录建立的。年龄和性别是影响参考范围的最重要因素,在使用应变超声心动图时应予以考虑。
Myocardial deformation by echocardiographic strain imaging is a key measurement in cardiology, providing valuable diagnostic and prognostic information. Reference ranges for strain should be established from large healthy populations with minimal methodologic biases and variability.
The aim of this study was to establish echocardiographic reference ranges, including lower normal limits of global strains for all 4 cardiac chambers, by
guideline-directed dedicated views from a large healthy population and to evaluate the influence of subject-specific characteristics on strain.
In total, 1,329 healthy participants from HUNT4Echo, the echocardiographic substudy of the 4th wave of the Trøndelag Health Study, were included. Echocardiographic recordings specific for each chamber were optimized according to current recommendations. Two experienced sonographers recorded all echocardiograms using GE HealthCare Vivid E95 scanners. Analyses were performed by experts using GE HealthCare EchoPAC.
The reference ranges for left ventricular (LV) global longitudinal strain and right ventricular free-wall strain were -24% to -16% and -35% to -17%, respectively. Correspondingly, left atrial (LA) and right atrial (RA) reservoir strains were 17% to 49% and 17% to 59%. All strains showed lower absolute values with higher age, except for LA and RA contractile strains, which were higher. The feasibility for strain was overall good (LV 96%, right ventricular 83%, LA 94%, and RA 87%). All chamber-specific strains were associated with age, and LV strain was associated with sex.
Reference ranges of strain for all cardiac chambers were established based on
guideline-directed chamber-specific recordings. Age and sex were the most important factors influencing reference ranges and should be considered when using strain echocardiography.