Abstract：
Continuous technologic development and updated recommendations for image acquisitions creates a need to update the current normal reference ranges for echocardiography. The best method of indexing cardiac volumes is unknown.
The authors used 2- and 3-dimensional echocardiographic data from a large cohort of healthy individuals to provide updated normal reference data for dimensions and volumes of the cardiac chambers as well as central Doppler measurements.
In the fourth wave of the HUNT (Trøndelag Health) study in Norway 2,462 individuals underwent comprehensive echocardiography. Of these, 1,412 (55.8% women) were classified as normal and formed the basis for updated normal reference ranges. Volumetric measures were indexed to body surface area and height in powers of 1 to 3.
Normal reference data for echocardiographic dimensions, volumes, and Doppler measurements were presented according to sex and age. Left ventricular ejection fraction had lower normal limits of 50.8% for women and 49.6% for men. According to sex-specific age groups, the upper normal limits for left atrial end-systolic volume indexed to body surface area ranged from 44 mL/m2 to 53 mL/m2, and the corresponding upper normal limit for right ventricular basal dimension ranged from 43 mm to 53 mm. Indexing to height raised to the power of 3 accounted for more of the variation between sexes than indexing to body surface area.
The authors present updated normal reference values for a wide range of echocardiographic measures of both left- and right-side ventricular and atrial size and function from a large healthy population with a wide age-span. The higher upper normal limits for left atrial volume and right ventricular dimension highlight the importance of updating reference ranges accordingly following refinement of echocardiographic methods.
The authors used 2- and 3-dimensional echocardiographic data from a large cohort of healthy individuals to provide updated normal reference data for dimensions and volumes of the cardiac chambers as well as central Doppler measurements.
In the fourth wave of the HUNT (Trøndelag Health) study in Norway 2,462 individuals underwent comprehensive echocardiography. Of these, 1,412 (55.8% women) were classified as normal and formed the basis for updated normal reference ranges. Volumetric measures were indexed to body surface area and height in powers of 1 to 3.
Normal reference data for echocardiographic dimensions, volumes, and Doppler measurements were presented according to sex and age. Left ventricular ejection fraction had lower normal limits of 50.8% for women and 49.6% for men. According to sex-specific age groups, the upper normal limits for left atrial end-systolic volume indexed to body surface area ranged from 44 mL/m2 to 53 mL/m2, and the corresponding upper normal limit for right ventricular basal dimension ranged from 43 mm to 53 mm. Indexing to height raised to the power of 3 accounted for more of the variation between sexes than indexing to body surface area.
The authors present updated normal reference values for a wide range of echocardiographic measures of both left- and right-side ventricular and atrial size and function from a large healthy population with a wide age-span. The higher upper normal limits for left atrial volume and right ventricular dimension highlight the importance of updating reference ranges accordingly following refinement of echocardiographic methods.
摘要：
背景：持续的技术发展和更新的图像采集建议需要更新当前的超声心动图正常参考范围。索引心脏体积的最佳方法未知。
目的：作者使用了大量健康人群的二维和三维超声心动图数据，为心腔的尺寸和体积以及中央多普勒测量提供更新的正常参考数据。
方法：在挪威的HUNT（TrøndelagHealth）研究的第四波中，有2,462名个体接受了全面的超声心动图检查。其中,1,412（55.8％的女性）被归类为正常，并构成了更新的正常参考范围的基础。体积测量以1至3的幂索引到身体表面积和高度。
结果：超声心动图尺寸的正常参考数据，卷,根据性别和年龄进行多普勒测量。女性左心室射血分数的正常下限为50.8％，男性为49.6％。根据特定性别年龄组，左心房收缩末期容积相对于体表面积的正常上限为44mL/m2~53mL/m2,右心室基底尺寸的相应正常上限为43mm~53mm.身高指数提高到3的幂，比体表面积指数占两性之间的差异更大。
结论：作者提供了大量年龄跨度较大的健康人群的左、右心室和心房大小和功能超声心动图测量值的更新的正常参考值。左心房容积和右心室尺寸的较高正常上限突出了在超声心动图方法改进后相应更新参考范围的重要性。
目的：作者使用了大量健康人群的二维和三维超声心动图数据，为心腔的尺寸和体积以及中央多普勒测量提供更新的正常参考数据。
方法：在挪威的HUNT（TrøndelagHealth）研究的第四波中，有2,462名个体接受了全面的超声心动图检查。其中,1,412（55.8％的女性）被归类为正常，并构成了更新的正常参考范围的基础。体积测量以1至3的幂索引到身体表面积和高度。
结果：超声心动图尺寸的正常参考数据，卷,根据性别和年龄进行多普勒测量。女性左心室射血分数的正常下限为50.8％，男性为49.6％。根据特定性别年龄组，左心房收缩末期容积相对于体表面积的正常上限为44mL/m2~53mL/m2,右心室基底尺寸的相应正常上限为43mm~53mm.身高指数提高到3的幂，比体表面积指数占两性之间的差异更大。
结论：作者提供了大量年龄跨度较大的健康人群的左、右心室和心房大小和功能超声心动图测量值的更新的正常参考值。左心房容积和右心室尺寸的较高正常上限突出了在超声心动图方法改进后相应更新参考范围的重要性。
