reductionism

还原论
  • 文章类型: Journal Article
    在这篇文章中,我们分析了研究人员如何使用种族和种族类别参考遗传学和基因组学。我们表明,当涉及到在遗传学和基因组学中使用亚类时,仍然存在相当大的概念性“混乱”(尽管关于该主题的广泛和普遍的辩论),除其他外,这使得难以正确比较和解释使用亚类的研究。并从中得出结论。最后,我们简单地重建了遗传学家(以及其他研究人员提到遗传方法和解释)特别暴露于的一些还原论的偏见,我们分析了这个问题的背景下的生物分类。我们的作品构成了一部小说,对生物医学和健康研究中关于报告种族和种族的辩论的深入贡献。首先,我们借助最近在医学期刊上发表的关于COVID-19的论文样本,重建了研究人员在研究中隐含的种族本体论的理论背景假设。其次,我们使用还原论偏见的类型学来参考遗传学和基因组学来解决小麦类别的生物学化问题。
    In this article, we analyse how researchers use the categories of race and ethnicity with reference to genetics and genomics. We show that there is still considerable conceptual \"messiness\" (despite the wide-ranging and popular debate on the subject) when it comes to the use of ethnoracial categories in genetics and genomics that among other things makes it difficult to properly compare and interpret research using ethnoracial categories, as well as draw conclusions from them. Finally, we briefly reconstruct some of the biases of reductionism to which geneticists (as well as other researchers referring to genetic methods and explanations) are particularly exposed to, and we analyse the problem in the context of the biologization of ethnoracial categories. Our work constitutes a novel, in-depth contribution to the debate about reporting race and ethnicity in biomedical and health research. First, we reconstruct the theoretical background assumptions about racial ontology which researchers implicitly presume in their studies with the aid of a sample of recent papers published in medical journals about COVID-19. Secondly, we use the typology of the biases of reductionism to the problem of biologization of ethnoracial categories with reference to genetics and genomics.
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  • 文章类型: Journal Article
    这篇文章提出了弗朗兹·布伦塔诺的经验心理学中最重要和几乎被遗忘的论点,这对心理学研究的概念化和方法具有重要意义。心理学项目,早在1874年推出,仍然处于主流经验心理学的边缘,但这是KazimierzTwardowski和他的学生的起点。布伦塔诺思想在20世纪的延续和发展可以极大地丰富和拓宽心理学的理论和实证视角。这主要适用于还原论和心理现象的社会层面。
    The article presents the most important and almost forgotten theses of Franz Brentano\'s empirical psychology, which have significance for conceptualization and the method of psychological research. The psychology programme, introduced as early as 1874, remains on the fringes of mainstream empirical psychology, but it was the starting point for Kazimierz Twardowski and his students. The continuation and development of Brentano\'s thought in the twentieth century can significantly enrich and broaden psychology\'s theoretical and empirical perspective. This applies primarily to reductionism and the social dimension of mental phenomena.
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  • 文章类型: Journal Article
    目的:本研究旨在批判性地分析澳大利亚当前和拟议的减少添加糖消费的政策措施。过量食用添加糖是一个重要的公共卫生营养问题。相互竞争的利益,利益相关者之间的价值观和信念意味着他们对哪些政策行动更可取,以减少添加糖的消耗有不同的看法。
    方法:使用目的性的半结构化访谈,滚雪球抽样和政策映射。政策行动按两个框架分类:感知(例如,行为改变沟通、食物环境和食物系统)和变化命令(例如,第一顺序:技术调整,第二个顺序:改革体制,第三级:改造系统)。
    方法:澳大利亚。
    方法:来自食品行业的22个利益相关者,食品监管,政府,公共卫生团体和学术界。
    结果:所有建议和现有的政策行动都针对食品环境/行为的变化;大多数被评估为一级变化,和还原主义者(特定的营养)。对政策行动的影响包括行业力量,利益相关者碎片化,政府意识形态/政治意愿和公众压力。很少有利益相关者考虑到政策行动的潜在风险,特别是非营养甜味剂替代或其他政策的机会成本。
    结论:澳大利亚减少添加糖消耗的大部分政策行动都是还原性的。参考特定的营养素,一级政策行动可以反映既得利益的影响,营养科学和政策的历史上占主导地位的还原论取向,以及追求二阶或三阶变化的感知难度。仅采取一级政策行动可能会导致“令人遗憾的”替代,并为旨在调整更广泛的粮食系统的更全面政策创造机会成本。
    OBJECTIVE: This study aimed to critically analyse Australia\'s current and proposed policy actions to reduce added sugar consumption. Over-consumption of added sugar is a significant public health nutrition issue. The competing interests, values and beliefs among stakeholders mean they have disparate views regarding which policy actions are preferable to reduce added sugar consumption.
    METHODS: Semi-structured interviews using purposive, snowball sampling and policy mapping. Policy actions were classified by two frameworks: NOURISHING (e.g. behaviour change communication, food environment and food system) and the Orders of Change (e.g. first order: technical adjustments, second order: reforming the system, third order: transforming the system).
    METHODS: Australia.
    METHODS: Twenty-two stakeholders from the food industry, food regulation, government, public health groups and academia.
    RESULTS: All proposed and existing policy actions targeted the food environment/behaviour change; most were assessed as first-order changes, and reductionist (nutrient specific) in nature. Influences on policy actions included industry power, stakeholder fragmentation, government ideology/political will and public pressure. Few stakeholders considered potential risks of policy actions, particularly of non-nutritive sweetener substitution or opportunity costs for other policies.
    CONCLUSIONS: Most of Australia\'s policy actions to reduce added sugar consumption are reductionist. Preferencing nutrient specific, first-order policy actions could reflect the influence of vested interests, a historically dominant reductionist orientation to nutrition science and policy, and the perceived difficulty of pursuing second- or third-order changes. Pursuing only first-order policy actions could lead to \'regrettable\' substitutions and creates an opportunity cost for more comprehensive policy aimed at adjusting the broader food system.
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  • 文章类型: Journal Article
    Gaining insight into the response of surface ozone (O3) formation to its precursors plays an important role in the policy-making of O3 pollution control. However, the real atmosphere is an open and dissipative system, and its complexity poses a great challenge to the study of nonlinear relations between O3 and its precursors. At present, model-based methods based on reductionism try to restore the real atmospheric photochemical system, by coupling meteorological model and chemical transport model in temporal and spatial resolution completely. Nevertheless, large inconsistencies between predictions and true values still exist, due to the great uncertainty originated from emission inventory, photochemical reaction mechanism and meteorological factors. Recently, based on field observations, some nonlinear methods have successfully revealed the complex emergent properties (long-term persistence, multi-fractal, etc) in coupling correlation between O3 and its precursors at different time scales. The emergent properties are closely associated with the intrinsic dynamics of atmospheric photochemical system. Taking them into account when building O3 prediction model, is helpful to reduce the uncertainty in the results. Nonlinear methods (fractal, chaos, etc) based on holism can give new insights into the nonlinear relations between O3 and its precursors. Changes of thinking models in methodology are expected to improve the precision of forecasting O3 concentration. This paper has reviewed the advances of different methods for studying the sensitivity of O3 formation to its precursors during the past few decades. This review highlights that it is necessary to incorporate the emergent properties obtained by nonlinear methods into the modern models, for assessing O3 formation under combined air pollution environment more accurately. Moreover, the scaling property of coupling correlation detected in the real observations of O3 and its precursors could be used to test and improve the simulation performance of modern models.
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  • 文章类型: Journal Article
    One of the principal goals of comparative biology is the elucidation of mechanisms by which organisms adapt to different environments. The study of enzyme structure, function, and stability has contributed significantly to this effort, by revealing adaptation at a molecular level. Comparative biochemistry, including enzymology, necessarily pursues a reductionist approach in describing the function and structure of biomolecules, allowing more straightforward study of molecular systems by removing much of the complexity of their biological milieu. Although this reductionism has allowed a remarkable series of discoveries linking chemical processes to metabolism and to whole-organism function in the context of the environment, it also has the potential to mislead when careful consideration is not made of the simplifying assumptions inherent to such research. In this review, a brief history of the growth of enzymology, its reliance on a reductionist philosophy, and its contributions to our understanding of biological systems is given. Examples then are provided of research techniques, based on a reductionist approach, that have advanced our knowledge about enzyme adaptation to environmental stresses, including stability assays, enzyme kinetics, and the impact of solute composition on enzyme function. In each case, the benefits of the reductionist nature of the approach is emphasized, notable advances are described, but potential drawbacks due to inherent oversimplification of the study system are also identified.
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  • 文章类型: Journal Article
    当代生物学的科学方法是西方还原论传统认为具有普遍性的一些文化思想的结果。对文化的研究,对现实和生活的象征性和历史方法为我们提供了重要的教训,说明将东方整体观点纳入生活研究的必要性。这是认识论和本体论的增强,它提供了更强大和有洞察力的方式来处理生活及其理解。
    Contemporary scientific approaches to Biology are the result of some cultural ideas considered as universal by Western reductionist traditions. The study of the cultural, symbolic and historical approaches to reality and Life provides us important lessons about the necessity of integrating Eastern holistic views into the study of Life. This is both an epistemological and ontological enhancement which provides more powerful and insightful ways to deal with Life and its understanding.
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  • 文章类型: Journal Article
    进化保存了执行许多功能的“经济”系统,更快或更好,少。例如,三到五种类型的白细胞可以抵御数千种病原体。用这么少的东西实现这么多,生物系统结合了它们有限的元素,创造复杂的结构。然而,流行的研究范式是还原论。关注传染病,这里描述了还原论和非还原论观点。文献表明,还原论与信息丢失和错误有关,而非简化操作可以从相同的数据中提取更多的信息。当被设计为捕获一对多/多对一的交互时-包括使用连接连续观测对的箭头-非简化主义者(时空)构造从所有维度消除了数据可变性,除了沿着一条线,而箭头描述了沿线发生的时间变化的方向性。要验证非还原性操作检测到的模式,需要简化程序。综合(非还原论和还原论)方法可以(i)区分免疫学和统计学上不同的数据子集;(ii)区分假阴性和阳性错误;(iii)区分疾病阶段;(iv)体内捕获,考虑患者的多层次互动,微生物,和抗生素介导的反应;和(V)评估动力学。集成方法提供了可重复的和生物学上可解释的信息。
    Evolution has conserved \"economic\" systems that perform many functions, faster or better, with less. For example, three to five leukocyte types protect from thousands of pathogens. To achieve so much with so little, biological systems combine their limited elements, creating complex structures. Yet, the prevalent research paradigm is reductionist. Focusing on infectious diseases, reductionist and non-reductionist views are here described. The literature indicates that reductionism is associated with information loss and errors, while non-reductionist operations can extract more information from the same data. When designed to capture one-to-many/many-to-one interactions-including the use of arrows that connect pairs of consecutive observations-non-reductionist (spatial-temporal) constructs eliminate data variability from all dimensions, except along one line, while arrows describe the directionality of temporal changes that occur along the line. To validate the patterns detected by non-reductionist operations, reductionist procedures are needed. Integrated (non-reductionist and reductionist) methods can (i) distinguish data subsets that differ immunologically and statistically; (ii) differentiate false-negative from -positive errors; (iii) discriminate disease stages; (iv) capture in vivo, multilevel interactions that consider the patient, the microbe, and antibiotic-mediated responses; and (v) assess dynamics. Integrated methods provide repeatable and biologically interpretable information.
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