硬化性苔藓(LS)是一种典型的生殖器区域的慢性炎症性皮肤病,罕见地累及外生区,尤其是面部。LS治疗管理具有挑战性,和常见的疗法,包括局部和全身皮质类固醇,局部钙调磷酸酶抑制剂,手术往往是无效的。在这里,我们介绍了一例LS发生在1名36岁女孩中,她的面部受累对全身性糖皮质激素和外用他克莫司治疗产生抵抗.考虑到一个敏感地区的参与,病人的年龄很小,以及使用光动力疗法治疗面部皮肤疾病的一致临床经验,我们开始使用5-氨基乙酰丙酸(ALA)-光动力疗法(PDT),每月一次,剂量为37J/cm2.我们将我们的病例与文献中的其他八名面部LS患者进行了比较,并进行了不同的治疗。
Lichen sclerosus (LS) is a chronic inflammatory dermatosis typical of the genital region, with rare involvement of extragenital areas and particularly the face. LS therapeutic management is challenging, and common therapies including topical and systemic corticosteroids, topical calcineurin inhibitors, surgery are often ineffective. Herein, we present a
case of LS occurred in a 36-year-old girl with facial involvement resistant to therapy with systemic corticosteroids and topical tacrolimus. Considering the involvement of a sensitive area, the young age of the patient, and the consistent clinical experience in using photodynamic therapy for the treatment of facial skin disease, we started a treatment with topical 5-aminolevulinic acid (ALA)-photodynamic therapy (PDT) with a dosage of 37 J/cm2 once a month. We compared our
case with eight other facial LS patients from the literature and treated differently.