背景:局部光动力疗法(PDT)是针对各种皮肤肿瘤病症的既定治疗方式。在欧洲,最初需要用红光照射,光化性角化病(AK)的PDT现在也可以在暴露于日光的情况下进行,该日光已被临床证明与红光一样有效且疼痛程度较小。
目的:在本文中,我们建议对AktiliteCL128(红色光源)PDT的常规方案和日光PDT的欧洲共识方案进行比较-假设暴露在晴朗的晴天或阴天-通过数学建模用氨基乙酰丙酸甲酯治疗AK.
方法:这个已经发表的模型是基于迭代过程交替确定局部注量率和更新局部光学特性,能够估计由治疗引起的局部损伤。
结果:欧洲在晴天和阴天的日光PDT共识协议规定,平均而言,6.50和1.79倍的PDT局部损害在治疗结束时,比使用传统方案获得的AktiliteCL128PDT,分别。
结论:结果分析表明,甚至在阴天表演,与AktiliteCL128的有效常规协议相比,欧洲日光PDT共识协议导致更高的PDT局部损害。
BACKGROUND: Topical photodynamic therapy (PDT) is an established treatment modality for various dermato-oncologic conditions. In Europe, initially requiring irradiation with red light, PDT of actinic keratosis (AK) can now also be carried out with exposure to daylight that has been clinically proven to be as effective as and less painful than red light.
OBJECTIVE: In this paper, we propose a comparison between the conventional protocol for Aktilite CL 128 (red light source) PDT and the European
consensus protocol for daylight PDT - with the exposure is assumed to be performed during either a clear sunny day or an overcast day - in the treatment of AK with methyl aminolevulinate through a mathematical modeling.
METHODS: This already published modeling that is based on an iterative procedure alternating determination of the local fluence rate and updating of the local optical properties enables to estimate the local damage induced by the therapy.
RESULTS: The European
consensus protocol for daylight PDT during a sunny day and an overcast day provides, on average, 6.50 and 1.79 times higher PDT local damages at the end of the treatment than those obtained using the conventional protocol for Aktilite CL 128 PDT, respectively.
CONCLUSIONS: Results analysis shows that, even performed during an overcast day, the European
consensus protocol for daylight PDT leads to higher PDT local damages than the efficient conventional protocol for Aktilite CL 128.