■本研究旨在评估lucite锥涂抹器(LCA)的质量,伊拉斯谟MC癌症研究所浅表热疗的标准涂药器,使用最新的质量保证指南,从而验证其可行性。
■对可用于临床治疗的六个LCA中的每一个进行评估。使用红外摄像机在脂肪肌肉模仿体模的不同层上评估温度分布。最高温度升高,热有效穿透深度(TEPD),和热有效场大小(TEFS)被用作质量指标。通过与模拟结果的比较,验证了实验结果,使用规范的体模模型和从CT成像分割的真实体模模型。
■发现所有实验的脂肪-肌肉体模在2厘米深度处的最大温度升高超过6°C。当使用规范体模模型时,模拟数据和实验数据之间的平均负差为1.3°C。当使用实际模型时,该值降低到0.4°C的平均负差值。模拟和测量的TEPD在两种模拟情况下都显示出良好的一致性,而TEFS存在差异。
■当单独使用或在阵列配置中使用时,LCA通过了所有关于表面热疗输送的QA指南要求。诸如天线效率和传热系数之类的参数的进一步表征将有益于将实验结果转化为模拟值。实施质量保证准则既耗时又苛刻,需要仔细准备和正确设置天线元件。
This study aimed to assess the quality of the lucite cone applicator (LCA), the standard applicator for superficial hyperthermia at the Erasmus MC Cancer Institute, using the most recent quality assurance
guidelines, thus verifying their feasibility.
The assessment was conducted on each of the six LCAs available for clinical treatments. The temperature distribution was evaluated using an infrared camera across different layers of a fat-muscle mimicking phantom. The maximum temperature increase, thermal effective penetration depth (TEPD), and thermal effective field size (TEFS) were used as quality metrics. The experimental results were validated through comparison with simulated results, using a canonical phantom model and a realistic phantom model segmented from CT imaging.
A maximum temperature increase above 6 °C at 2 cm depth in the fat-muscle phantom for all the experiments was found. A mean negative difference between simulated and experimental data was of 1.3 °C when using the canonical phantom model. This value decreased to a mean negative difference of 0.4 °C when using the realistic model. Simulated and measured TEPD showed good agreement for both in silico scenarios, while discrepancies were present for TEFS.
The LCAs passed all QA
guidelines requirements for superficial hyperthermia delivery when used singularly or in an array configuration. A further characterization of parameters such as antenna efficiency and heat transfer coefficients would be beneficial for translating experimental results to simulated values. Implementing the QA
guidelines was time-consuming and demanding, requiring careful preparation and correct setup of antenna elements.