背景:据我们所知,这是兽医文献中首次报道女性生殖系统浸润T细胞淋巴瘤。
方法:1.5岁,由于黑便和持续三周的缺氧,完整的雌性金毛被转诊。发热(40.5℃),心动过速,呼吸暂停,苍白的粘膜,在体格检查中发现了化脓性阴道分泌物。血液分析显示白细胞增多,贫血,低蛋白血症,乳酸和C反应蛋白水平升高。在腹部X线摄影上,由于位于腹部中部的椭圆形肿块(13cm×8.7cm),小肠中度偏离。一种扩大的管状结构,具有位于膀胱背侧至腹部中部的软组织不透明,和一个椭圆形的块(5.28厘米×3.26厘米),怀疑是位于第六至第七腰椎水平的内侧髂淋巴结。腹部超声检查显示子宫角腔内气体和液体严重增厚,泌尿生殖系统周围的圆形淋巴结肿大,和腹腔中的游离液体。基于这些结果,有人怀疑是子宫积脓,剖腹探查术用于卵巢子宫切除术。切除的卵巢和子宫肉眼可见肥大。卵巢和子宫的组织病理学检查显示,大型圆形细胞的肿瘤增生,对CD3具有很强的免疫反应性,表明T细胞淋巴瘤。因此,这只小狗被诊断为生殖器淋巴瘤。
结论:本报告描述了T细胞淋巴瘤浸润幼犬的子宫和卵巢,这很少被诊断出来,可以帮助鉴别诊断幼犬的生殖器疾病。
BACKGROUND: To the best of our knowledge, this is the first report of female genital system infiltration of T-cell lymphoma in veterinary literature.
METHODS: A 1.5-year-old, intact female Golden Retriever was referred due to melena and hyporexia that lasted for three weeks. Fever (40.5℃), tachycardia, tachypnoea, pale mucous membranes, and purulent vaginal discharge were identified on physical examination. Blood analyses revealed leucocytosis, anaemia, hypoalbuminemia, and increased lactate and C-reactive protein levels. On abdominal radiography, the small intestine was moderately deviated because of an oval-shaped mass (13 cm × 8.7 cm) located in the mid-abdomen. An enlarged tubular-shaped structure that had the opacity of soft tissue located in dorsal to the bladder to the middle of the abdomen, and an oval-shaped mass (5.28 cm × 3.26 cm), which was suspected to be a medial iliac lymph node located at the sixth to seventh lumbar level. Abdominal ultrasonography revealed gas and fluid in the lumen of the uterine horn with a severely thickened wall, round enlarged lymph nodes around the genitourinary system, and free fluid in the abdominal cavity. Based on these results,
pyometra was suspected, and an exploratory laparotomy was performed for ovariohysterectomy. The resected ovary and uterus were macroscopically hypertrophied. Histopathological examination of the ovary and uterus revealed neoplastic proliferation of large round cells with strong immunoreactivity for CD3, indicating T-cell lymphoma. Therefore, the young dog was diagnosed with genital lymphoma.
CONCLUSIONS: The present report describes T-cell lymphoma infiltrating the uterus and ovaries in a young dog, which is rarely diagnosed and could aid in the differential diagnosis of genital diseases in young dogs.