背景:电视胸腔镜手术(VATS)肺叶切除术是目前治疗早期非小细胞肺癌(NSCLC)的推荐方法。到目前为止,已经提出了不同的VATS方法,一种技术相对于另一种技术的实际优势仍在争论中。我们研究的目的是比较早期肺癌患者肺叶切除术中单门VATS和三门VATS的术后疼痛和镇痛药物消耗。
方法:本研究是单中心,prospective,双臂,平行组,随机对照试验。它旨在比较单孔视频辅助胸腔镜手术(u-VATS)和三端口视频辅助胸腔镜手术(t-VATS)在术后疼痛方面。该试验将以1:1的随机分组方式招募120名患者。主要结果是评估镇痛药物的消耗。次要结果是术后疼痛测量,术后肺功能评估,肺叶切除术后代谢恢复。
结论:选择何种VATS方法来治疗接受肺切除术的患者主要取决于外科医生的偏好;因此,很难证明一种VATS技术是否优于另一种。此外,不同中心的术后镇痛方案一致不同.迄今为止,只有少数研究评估了最流行的VATS技术的效果。没有证据表明多端口VATS和u-VATS在术后疼痛方面存在差异。我们希望我们的试验结果将为这些不同手术方法的结果提供有价值的信息。
背景:ClinicalTrials.govNCT03240250。2017年8月7日注册;追溯注册。
BACKGROUND: Video-assisted thoracoscopic surgery (VATS) lobectomy is currently the recommended approach for treating early-stage non-small cell lung cancer (NSCLC). Different VATS approaches have been proposed so far, and the actual advantages of one technique over the other are still under debate. The aim of our
study is to compare postoperative pain and analgesic drug consumption in uniportal VATS and triportal VATS for pulmonary lobectomy in early-stage lung cancer patients.
METHODS: This
study is a single-center, prospective, two-arm, parallel-group, randomized controlled
trial. It is designed to compare uniportal video-assisted thoracic surgery (u-VATS) and three-port video-assisted thoracic surgery (t-VATS) in terms of postoperative pain. The
trial will enroll 120 patients with a 1:1 randomization. The primary outcome is the assessment of analgesic drug consumption. Secondary outcomes are postoperative pain measurement, evaluation of postoperative pulmonary function, and metabolic recovery after pulmonary lobectomy.
CONCLUSIONS: The choice of which VATS approach to adopt for treating patients undergoing pulmonary resection mostly depends on the surgeon\'s preferences; therefore, it is hard to prove whether one VATS technique is superior to the other. Moreover, postoperative analgesic protocols vary consistently among different centers. To date, only a few studies have evaluated the effects of the most popular VATS techniques. There is no evidence about the difference between multiport VATS and u-VATS in terms of postoperative pain. We hope that the results of our
trial will provide valuable information on the outcomes of these different surgical approaches.
BACKGROUND: ClinicalTrials.gov NCT03240250 . Registered on 07 August 2017; retrospectively registered.