目的:本研究的目的是调查多瘤病毒感染与肺癌的合并患病率和可能的相关性。
方法:通过从主要的在线数据库中确定相关的横断面和病例对照研究,进行了系统的出版物检索。异质性,OR,通过荟萃分析和森林地块,将相应的95%CI应用于所有研究。使用随机效应模型来计算总体汇总患病率。将绘制对数转换OR及其相关的对数标准误差(OR)的漏斗图的视觉检查与Begg和Egger测试相结合,以检查发表偏倚的存在和影响。使用Stata软件v.14.1进行分析。
结果:23篇文章(33个数据集)被纳入荟萃分析,其中14个数据集为病例/对照,其余为横断面研究。肺癌患者的合并多瘤病毒感染率为0.06%(0.02-0.11%)。在亚组分析中,JCV的合并患病率,MCPyV,KI,SV40,BKV,WU,MU,STL为21%,7%,6%,2%,0%,0%,0%,分别为0%。已发现多瘤病毒感染与肺癌之间存在关联[汇总OR6.33(95%CI(1.76-22.77);I2=67.45%)]。亚组分析,根据病毒类型,显示MCPyV与肺癌之间有很强的相关性[汇总OR13.61(95%CI2.41-76.59;I2=40.0%)]。尽管肺癌组织中JCVDNA的患病率很高,对病例对照研究的分析表明,JCV与肺癌无关,并且不会增加肺癌的风险.
结论:本研究显示多瘤病毒感染与肺癌之间存在显著关联。结果还显示,在肺部肿瘤患者中,多瘤病毒的合并患病率为6%。总之,本研究的结果表明,Merkel细胞多瘤病毒感染是肺癌的潜在危险因素。
OBJECTIVE: The objective of this study was to investigate the pooled prevalence and possible association between
polyomavirus infection and lung cancer.
METHODS: A systematic publication search was conducted by identifying relevant cross-sectional and case-control studies from major online databases. Heterogeneity, OR, and corresponding 95 % CI were applied to all studies through meta-analysis and forest plot. Random effects models were used to calculate the overall pooled prevalence. Visual inspection of a funnel plot plotting the log-transformed OR and its associated standard error of the log (OR) was combined with the Begg and Egger test to examine the presence and influence of publication bias. Analyzes were performed using Stata software v.14.1.
RESULTS: 23 articles (33 datasets) were included in the meta-analysis, of which 14 datasets were case/control and the rest were cross-sectional studies. The pooled
polyomavirus infection rate in lung cancer patients was 0.06 % (0.02-0.11 %). In subgroup analysis, the pooled prevalence of JCV, MCPyV, KI, SV40, BKV, WU, MU, and STL was 21 %, 7 %, 6 %, 2 %, 0 %, 0 %, 0 %, and 0 % respectively. An association has been found between
polyomavirus infection and lung cancer [summary OR 6.33 (95 % CI (1.76-22.77); I2=67.45 %)]. The subgroup analysis, based on the virus type, showed a strong association between MCPyV and lung cancer [summary OR 13.61 (95 % CI 2.41-76.59; I2=40.0 %)]. despite the high prevalence of JCV DNA in lung cancer tissue, analysis of case-control studies showed that JCV is not associated with lung cancer and does not increase the risk of lung cancer.
CONCLUSIONS: This study showed a significant association between polyomaviruses infection with lung cancer. The results also revealed a pooled prevalence of 6 % for polyomaviruses in lung tumor patients. Altogether, the findings of the present work suggest that Merkel cell
polyomavirus infection is a potential risk factor for lung cancer.