PDF(Pubmed)
Abstract：
Viruses rely on host-cell machinery in order to invade host cells and carry out a successful infection. G-protein coupled receptor (GPCR)-mediated signaling pathways are master regulators of cellular physiological processing and are an attractive target for viruses to rewire cells during infection. In particular, the GPCR-associated scaffolding proteins β-arrestins and GPCR signaling effectors G-protein receptor kinases (GRKs) have been identified as key cellular factors that mediate viral entry and orchestrate signaling pathways that reprogram cells for viral replication. Interestingly, a broad range of viruses have been identified to activate and/or require GPCR-mediated pathways for infection, including polyomaviruses, flaviviruses, influenza virus, and SARS-CoV-2, demonstrating that these viruses may have conserved mechanisms of host-cell invasion. Thus, GPCR-mediated pathways highlight an attractive target for the development of broad antiviral therapies.
摘要：
病毒依靠宿主细胞机制来侵入宿主细胞并进行成功的感染。G蛋白偶联受体（GPCR）介导的信号通路是细胞生理过程的主要调节因子，并且是病毒在感染过程中重新连接细胞的有吸引力的靶标。特别是,GPCR相关支架蛋白β-抑制素和GPCR信号传导效应物G蛋白受体激酶(GRKs)已被确定为介导病毒进入和协调信号通路的关键细胞因子,这些信号通路为病毒复制重编程细胞.有趣的是,已鉴定出多种病毒激活和/或需要GPCR介导的感染途径，包括多瘤病毒，黄病毒,流感病毒,和SARS-CoV-2，表明这些病毒可能具有宿主细胞入侵的保守机制。因此，GPCR介导的途径突出了开发广泛抗病毒疗法的有吸引力的目标。
