随着生物医学领域的持续快速发展和对生物分子重要机制和药代动力学的理解,受控药物递送系统(CDDS)已经处于传统药物递送系统的最前沿。在过去的几年里,科学家们投入了无限的精力和时间来开发各种各样的赋形剂,特别是不同的聚合物,天然和合成。最近,纳米聚合物共混物的开发由于其惊人的性能而获得了值得注意的关注,如生物相容性,生物降解性,更重要的是,它们在体外和体内控制和持续药物释放中的关键作用。这些化合物对于改善靶向或受控药物和基因递送系统的问题具有许多有效的益处;因此,它们已广泛用于医疗和制药应用。此外,它们对伤口敷料非常有吸引力,纺织品,组织工程,和生物医学假体。在这个意义上,一些重要且可行的天然聚合物(即,壳聚糖(CS),淀粉和纤维素)和一些适用的合成物质(如聚乳酸-羟基乙酸共聚物(PLGA),聚(乳酸)(PLA)和聚乙醇酸(PGA)由于其具有吸引力和可再生的生物学特性,在过去的二十年中,它们的治疗效果发挥了不可或缺的作用。根据我们的数据,这是第一篇综述文章,重点介绍由各种天然和合成纳米生物聚合物组成的CDDS,为生物目的混合,主要是在过去的五年;其他评论刚刚简要提到了这种混合聚合物的使用。我们,此外,尝试在各种纳米共混系统之间进行比较,以改善持续和受控的药物释放行为。
With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first
review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.