背景技术液体超负荷相关的大B细胞淋巴瘤(FO-LBCL)是最近描述的恶性淋巴瘤,其表现为胸膜中的浆液性积液。腹膜,和/或心包,但没有可识别的淋巴瘤肿块。本报告描述了一名80岁男性出现胸腔积液的情况,并描述了FO-LBCL的诊断和管理方法。案例报告我们介绍了一例80岁的男性,他在工作中出现右胸腔积液和呼吸急促。最初的放射学评估提示右侧有胸腔积液,没有可识别的质量,鉴于患者的症状和影像学特征。随后,他接受了胸腔积液穿刺和活检。根据最初的病理评估,恶性淋巴瘤,非上皮性肿瘤,被认为是可能的,但是从反应性增殖细胞分化是困难的,鉴于患者的症状和细胞学特征。术后,组织病理学检查和免疫组织化学证实了FO-LBCL的诊断。随访1年后,病情有所进展,患者因复发死亡.结论本报告介绍了一例患有胸腔积液的老年男性的FO-LBCL病例,并描述了如何诊断和治疗这种罕见且最近描述的淋巴瘤。
BACKGROUND Fluid overload-associated large B-cell lymphoma (FO-LBCL) is a recently described malignant lymphoma that presents with serous effusions in the pleura, peritoneum, and/or pericardium but without an identifiable lymphoma mass. This report describes the case of an 80-year-old man who presented with a pleural effusion and describes the approach to diagnosis and management of FO-LBCL. CASE REPORT We present a case of an 80-year-old man who presented with right pleural effusion and shortness of breath at work. Initial radiological assessment suggested a pleural effusion on the right side, without an identifiable mass, given the patient\'s symptoms and imaging characteristics. Subsequently, he underwent a pleural fluid puncture and biopsy. Based on the initial pathological assessment, malignant lymphoma, a non-epithelial tumor, was considered likely, but differentiation from reactive proliferative cells was difficult, given the patient\'s symptoms and cytologic characteristics. Postoperatively, histopathological examination and immunohistochemistry confirmed a diagnosis of FO-LBCL. After 1 year of follow-up, the condition had progressed and the patient died due to recurrence. CONCLUSIONS This report has presented a case of FO-LBCL in an elderly man with pleural effusion and described how this rare and recently described lymphoma was diagnosed and managed.