新型冠状病毒的出现,SARS-CoV-2推动世界经历了本世纪的第一次大流行。任何针对这种RNA病毒的特异性药物尚未被发现,目前,感染COVID-19的患者正在接受对症治疗。在过去的几十年里,已经从印度药用植物中发明了许多具有潜在生物活性的多糖。许多多糖,如硫酸化的木甘露聚糖,木聚糖,果胶,岩藻依聚糖,葡聚糖,葡糖阿拉伯聚糖,和来自印度药用植物的阿拉伯木聚糖,已被证明具有抗病毒和免疫调节活性。植物多糖通过干扰病毒生命周期和抑制病毒与宿主细胞的附着而表现出抗病毒活性。摄入某些免疫刺激植物多糖也可以在一定程度上保护病毒。在不断寻找最有效药物的过程中,印度植物多糖可能作为对抗COVID-19的重要生物材料出现。这篇综述探讨了许多来自印度药用植物的多糖,这些多糖具有抗病毒和免疫调节活性。它的目的是提供有关组成的概述,分子量,多糖的分支构型和相关的生物活性,这对于将其分类为可能在病毒性疾病中诱导免疫反应的药物至关重要。
The emergence of the novel coronavirus, SARS-CoV-2 has pushed forward the world to experience the first pandemic of this century. Any specific drug against this RNA virus is yet to be discovered and presently, the COVID-19 infected patients are being treated symptomatically. During the last few decades, a number of polysaccharides with potential biological activities have been invented from Indian medicinal plants. Many polysaccharides, such as sulfated xylomannan, xylan, pectins, fucoidans, glucans, glucoarabinan, and arabinoxylan from Indian medicinal plants, have been shown to exhibit antiviral and immunomodulating activities. Plant polysaccharides exhibit antiviral activities through interference with the viral life cycle and inhibition of attachment of virus to host cell. Intake of certain immune stimulating plant polysaccharides may also protect from the virus to a certain extent. In process of continuous search for most potent drug, Indian plant polysaccharides may emerge as significant biomaterial to combat COVID-19. This
review explores a number of polysaccharides from Indian medicinal plants which showed antiviral and immunomodulating activities. It is aimed to provide an overview about the composition, molecular mass, branching configuration and related bioactivities of polysaccharides which is crucial for their classification as possible drug to induce immune response in viral diseases.