PDF(Pubmed)
Abstract：
Plant polysaccharides (PP) demonstrate a diverse array of biological and pharmacological properties. This comprehensive review aims to compile and present the multifaceted roles and underlying mechanisms of plant polysaccharides in various liver diseases. These diseases include non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), fibrosis, drug-induced liver injury (DILI), and hepatocellular carcinoma (HCC). This study aims to elucidate the intricate mechanisms and therapeutic potential of plant polysaccharides, shedding light on their significance and potential applications in the management and potential prevention of these liver conditions. An exhaustive literature search was conducted for this study, utilizing prominent databases such as PubMed, Web of Science, and CNKI. The search criteria focused on the formula \"(plant polysaccharides liver disease) NOT (review)\" was employed to ensure the inclusion of original research articles up to the year 2023. Relevant literature was extracted and analyzed from these databases. Plant polysaccharides exhibit promising pharmacological properties, particularly in the regulation of glucose and lipid metabolism and their anti-inflammatory and immunomodulatory effects. The ongoing progress of studies on the molecular mechanisms associated with polysaccharides will offer novel therapeutic strategies for the treatment of chronic liver diseases (CLDs).
摘要：
植物多糖（PP）表现出多种生物学和药理学特性。这篇综合综述旨在汇编和介绍植物多糖在各种肝脏疾病中的多方面作用和潜在机制。这些疾病包括非酒精性脂肪性肝病（NAFLD），酒精性肝病（ALD），纤维化，药物性肝损伤（DILI），和肝细胞癌（HCC）。本研究旨在阐明植物多糖的复杂机制和治疗潜力，阐明它们在这些肝脏疾病的管理和潜在预防中的重要性和潜在应用。本研究进行了详尽的文献检索，利用著名的数据库，如PubMed，WebofScience,和CNKI。搜索标准侧重于公式“（植物多糖肝病）NOT（综述）”，以确保在2023年之前包含原始研究文章。从这些数据库中提取并分析了相关文献。植物多糖表现出有希望的药理特性，特别是在调节葡萄糖和脂质代谢及其抗炎和免疫调节作用方面。与多糖相关的分子机制研究的持续进展将为慢性肝病（CLDs）的治疗提供新的治疗策略。
