行为遗传学研究和新的经验证据表明,抑郁症不能简单地用单个基因的影响来解释,但是基因-基因-环境的相互作用对于更好地理解抑郁症的病因很重要。本研究探讨了COMT基因Val158Met多态性的主要作用和交互作用,DAT1基因rs27072多态性,和同伴关系(即,同伴接受和拒绝)对青少年抑郁症状的影响。在1045名中国汉族青少年的样本中(Mage=12.34±0.47岁,50.1%的女孩),唾液样本,收集自我报告的抑郁症状和课堂内同伴提名.在控制了性别之后,年龄,和SES,COMT的三方互动,DAT1和同伴接受度显着同时预测了青少年抑郁症状。具有ValVal基因型COMT和CC基因型DAT1的青少年对接受更敏感,与携带其他组合基因型的同行相比。然而,在同伴拒绝的情况下,类似的三向互动并不显著.此外,分半验证通常复制了这些发现.更重要的是,这项研究强调了抑郁症的复杂多基因基础,并为抑郁症状病因中涉及的基因-基因-环境相互作用提供了支持。
Behavioral genetics studies and new empirical evidence suggest that depression cannot simply be explained by the influence of single genes but that gene-gene-environment interactions are important to better understanding the etiology of depression. The present
study investigated the main and interactive effects of COMT gene Val158Met polymorphism, DAT1 gene rs27072 polymorphism, and peer relationships (i.e., peer acceptance and rejection) on adolescent depressive symptoms. In a sample of 1045 Chinese Han adolescents (Mage = 12.34 ± 0.47 years, 50.1% girls), saliva samples, self-reported depressive symptoms and within-classroom peer nominations were collected. After controlling for gender, age, and SES, the three-way interaction of COMT, DAT1, and peer acceptance significantly concurrently predicted adolescent depressive symptoms. Adolescents with ValVal genotype of COMT and CC genotype of DAT1 were more sensitive to acceptance, compared to their counterparts carrying other combined genotypes. However, a similar three-way interaction was not significant in the case of peer rejection. Additionally, the split-half validation generally replicated these findings. More importantly, this
study underscores complex polygenic underpinnings of depression and lends support for the gene-gene-environment interactions implicated in the etiology of depressive symptoms.