未经证实:骨钙蛋白在小鼠的葡萄糖代谢中起作用,但是它与人体能量代谢的相关性是有争议的。尚未在婴儿和青少年中系统地解决其与儿科人群中能量代谢标志物的关系。
未经评估:本研究旨在评估tOC之间的平均差异,ucOC,健康儿童和1型或2型糖尿病(T1D或T2D)儿童的cOC以及这些骨分子与代谢标志物的相关性。
UNASSIGNED:根据PRISMA标准进行了系统回顾和元分析,以确定使用PubMed以英语和西班牙语发表的相关观察研究,Scopus,EBSCO,和WebofScience数据库。使用新城堡-渥太华量表评估偏倚风险。效应大小测量包括标准化平均差(SMD)和Pearson相关性。进行异质性和荟萃回归。
UNASSIGNED:纳入的20项研究是高质量的,包括3,000名接受tOC的儿科患者,cOC,或ucOC测量。在健康的受试者中,ucOC与WC和体重呈正相关,TOC与FPG呈正相关,HDL-c,WC,高度,和体重,TOC与HbA1c呈负相关。在糖尿病患者中,在T1D和T2D中,发现ucOC与HbA1c和血糖呈负相关,而在T1D中tOC与HbA1c呈负相关,但在T2D中则无负相关.在T2D中ucOC浓度较低,T1D,与对照组相比,血糖异常的患者。T1D中血清tOC浓度低于对照组。病人的年龄,高度,HbA1c影响血清tOC水平。
UNASSIGNED:骨钙蛋白参与儿科受试者的能量代谢,因为它始终与代谢和人体测量参数相关。
UNASSIGNED:https://www。crd.约克。AC.英国/普华永道/,标识符:CRD42019138283。
UNASSIGNED: Osteocalcin plays a role in glucose metabolism in mice, but its relevance in human energetic metabolism is controversial. Its relationship with markers of energetic metabolism in the pediatric population has not been systematically addressed in infants and adolescents.
UNASSIGNED: This study aims to assess the mean differences between tOC, ucOC, and cOC among healthy children and children with type 1 or type 2 diabetes (T1D or T2D) and the correlation of these bone molecules with metabolic markers.
UNASSIGNED: A systematic
review and metanalysis were performed following PRISMA criteria to identify relevant observational studies published in English and Spanish using PubMed, Scopus, EBSCO, and Web of Science databases. The risk of bias was assessed using New Castle-Ottawa scale. Effect size measures comprised standardized mean difference (SMD) and Pearson correlations. Heterogeneity and meta-regressions were performed.
UNASSIGNED: The 20 studies included were of high quality and comprised 3,000 pediatric patients who underwent tOC, cOC, or ucOC measurements. Among healthy subjects, there was a positive correlation of ucOC with WC and weight, a positive correlation of tOC with FPG, HDL-c, WC, height, and weight, and a negative correlation between tOC and HbA1c. Among diabetic subjects, a negative correlation of ucOC with HbA1c and glycemia in both T1D and T2D was found and a negative correlation between tOC and HbA1c in T1D but not in T2D. The ucOC concentrations were lower in T2D, T1D, and patients with abnormal glucose status than among controls. The serum concentrations of tOC concentrations were lower among T1D than in controls. The patient\'s age, altitude, and HbA1c influenced the levels of serum tOC.
UNASSIGNED: Osteocalcin is involved in energy metabolism in pediatric subjects because it is consistently related to metabolic and anthropometric parameters.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier: CRD42019138283.