pearldiver

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  • 文章类型: Journal Article
    方法:回顾性队列研究。
    目的:老年椎体压缩性骨折是最常见的与骨质疏松相关的骨折。使用大型国家数据库,本研究旨在研究和表征老年胸/腰椎压缩性骨折治疗的支撑趋势.
    方法:当前的研究利用了2015-2021年的PearlDiver数据库。确定了患有胸/腰椎压缩性骨折(第五胸椎至第五腰椎[T5-L5])的患者。排除标准包括年龄小于65岁或有感染或肿瘤指征的患者。在最初诊断为胸/腰椎压缩性骨折后90天内接受支具的患者被提取并表征为整体和骨折水平。进行多变量逻辑回归以评估与支撑趋势的相关性。
    结果:总共290.388例患者符合纳入标准,患有胸/腰椎压缩性骨折(胸腰椎交界处的发病率最高)。其中,仅对4263人(1.5%)规定了支撑,按级别划分的最大方差为1.5%。支撑的独立预测因素是地理区域(相对于东北部,西部WE赔率比[OR]1.31,中西部OR1.20),年龄较小(每十年1.27岁),女性(OR1.17),和ECI(每增加2个点OR1.02)(每个P<0.05)。
    结论:总体而言,目前的研究检查了超过25万名T5-L5压缩性骨折患者,发现只有1.5%的患者接受了支撑。这么低的百分比,支撑的最大预测指标是非临床(地理区域),强调这种做法的不一致,可能有助于开发治疗算法。
    METHODS: Retrospective cohort study.
    OBJECTIVE: Geriatric vertebral compression fractures are the most common fracture associated with osteoporosis. Using a large national database, the current study aimed to examine and characterize bracing trends for geriatric thoracic/lumbar compression fracture management.
    METHODS: The current study utilized the PearlDiver database from 2015-2021. Patients who suffered thoracic/lumbar compression fractures (fifth thoracic to the fifth lumbar vertebra [T5-L5]) were identified. Exclusion criteria included patients less than 65 years old or an indication of infection or neoplasm. Patients who received a brace within 90-days after the initial diagnosis of thoracic/lumbar compression fracture were abstracted and characterized overall and by fracture level. Multivariable logistic regression was performed to assess for correlation with bracing trends.
    RESULTS: In total 290 388 patients met inclusion criteria and suffered a thoracic/lumbar compression fracture (greatest incidence at the thoracolumbar junction). Of these, bracing was only prescribed for 4263 (1.5%), with the greatest variance of 1.5% by level. Independent predictors of bracing were geographic region (relative to northeast, west WE odds ratio [OR] 1.31, Midwest OR 1.20), younger age (OR 1.27 per decade), female sex (OR 1.17), and ECI (OR 1.02 per 2-point increase) (P < .05 for each).
    CONCLUSIONS: Overall, the current study examined over a quarter of a million patients who suffered a T5-L5 compression fractures and found that only 1.5% of patients were braced. This low percentage, and that greatest predictor for bracing was non-clinical (geographic region), highlight the inconsistency of this practice and may be useful for developing treatment algorithms.
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  • 文章类型: Journal Article
    后交叉韧带(PCL)损伤后的最佳处理仍然是一个活跃的研究领域,因为重建在技术上具有挑战性,并且在后膝关节中存在独特的风险。研究报告了各种并发症的发生率。
    为了描述再入院率,急诊科(ED)访问,和术后并发症90天内分离的PCL重建术(PCLR)中,国家队列,以更好地了解影响医生决定是否进行手术和非手术管理的围手术期变量。
    描述性流行病学研究。
    从2010年1月1日至2020年8月31日的PCLR在PearlDiver中被识别,国家行政数据库。合并韧带手术的患者和术后数据库活动少于90天的患者被排除在外。深静脉血栓形成,肺栓塞,手术部位感染,筋膜室综合征,并在手术后90天内发现血管事件,90天再入院和急诊就诊。在PearlDiver中建立Logistic回归模型,以计算ED利用率的优势比(OR)。
    最终队列包括1154例孤立的PCLR患者(平均年龄,34±16岁;62%男性)。大多数患者位于美国南部(n=417;36.1%),大多数人都有商业保险(n=992;86%)。90天的不良事件发生率如下:深静脉血栓形成(13;1.1%),肺栓塞(19;1.6%),手术部位感染(<11;<1%),筋膜室综合征(<11;<1%),血管事件(<11;<1%),重新接纳(13%,1.1%),和ED利用率(99;8.6%)。大多数急诊就诊(52%)发生在术后前2周。ED利用的预测因素包括Elixhauser合并症指数评分(OR=1.31每增加2分)和医疗补助保险(相对于商业保险OR=2.03)。
    当前的研究报告了孤立的PCLR后不良事件的发生率,国家队列。该结果为PCL损伤的最佳管理决策提供了重要的背景。
    UNASSIGNED: Optimal management after posterior cruciate ligament (PCL) injury remains an active area of research, as reconstruction is technically challenging and poses unique risks in the posterior knee. Studies have reported variable rates of complications.
    UNASSIGNED: To describe the rates of readmission, emergency department (ED) visits, and postoperative complications within 90 days of isolated PCL reconstruction (PCLR) in a large, national cohort to better understand the perioperative variables that influence a practitioner\'s decision of whether to pursue operative versus nonoperative management.
    UNASSIGNED: Descriptive epidemiology study.
    UNASSIGNED: PCLRs from January 1, 2010, through August 31, 2020, were identified in PearlDiver, a national administrative database. Patients with concomitant ligament surgery and those with fewer than 90 days of postoperative database activity were excluded. Deep vein thromboses, pulmonary embolisms, surgical site infections, compartment syndrome, and vascular events within 90 days of surgery were identified, as were 90-day readmissions and ED visits. Logistic regression models were built in PearlDiver to calculate odds ratios (ORs) for ED utilization.
    UNASSIGNED: The final cohort consisted of 1154 patients with isolated PCLR (mean age, 34 ± 16 years; 62% male). Most patients were located in the Southern United States (n = 417; 36.1%), and most had commercial insurance (n = 992; 86%). The 90-day rates of adverse events were as follows: deep vein thrombosis (13; 1.1%), pulmonary embolism (19; 1.6%), surgical site infection (<11; <1%), compartment syndrome (<11; <1%), vascular event (<11; <1%), readmission (13, 1.1%), and ED utilization (99; 8.6%). The majority of emergency department visits (52%) occurred in the first 2 weeks postoperatively. Predictive factors for ED utilization included Elixhauser Comorbidity Index score (OR = 1.31 per 2-point increase) and Medicaid insurance (OR = 2.03 relative to commercial insurance).
    UNASSIGNED: The current study reported rates of adverse events after isolated PCLR in a large, national cohort. The results provide important context for decisions about optimal management of PCL injury.
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  • 文章类型: Journal Article
    随着美国大麻使用的增加,非常需要了解与其使用相关的医疗并发症与手术人群的关系.主要研究了大麻的疼痛治疗质量,然而,很少有研究调查与使用它相关的术后并发症。因此,这项研究的目的是探讨使用大麻对脊柱手术并发症的影响,并将这些并发症发生率与阿片类药物相关并发症进行比较。
    这是一项使用PearlDiver数据库进行的回顾性研究。使用ICD代码,确定了2010年1月至2020年10月期间接受腰椎融合的40,989例患者,并将其分为3个研究组(即,control,已知阿片类药物使用障碍的患者,和被确定为大麻使用者的患者)。使用多变量逻辑回归评估了研究组之间在指数程序后30天内的并发症发生率和在指数程序后18个月的假关节发生率的差异。
    12.4%的研究人群使用大麻,38.8%的人患有已知的阿片类药物使用障碍。结果表明经历VTE的几率增加,缺氧,心肌梗塞,与对照组相比,阿片类药物和大麻使用者的心律失常;然而,在控制烟草使用时,大麻组出现并发症的几率没有增加.大麻使用者的假关节发生率(2.4%)高于对照组(1.1%)。
    使用大麻和阿片类药物的患者的假关节发生率明显高于对照组。然而,在控制烟草使用时,结果表明,大麻使用和伴随烟草使用之间可能存在负协同作用,这可能会影响骨融合。
    UNASSIGNED: With the increased use of cannabis in the US, there is a significant need to understand the medical complications associated with its use in relationship to a surgical population. Cannabis has mainly been studied with respect to its qualities of pain treatment, yet few studies have investigated post-surgical complications associated with its use. Therefore, the purpose of this study was to explore the effect of cannabis use on complications in spine surgery, and compare these complications rates to opioid-related complications.
    UNASSIGNED: This was a retrospective study conducted using the PearlDiver Database. Using ICD codes 40,989 patients that underwent lumbar spine fusion between January 2010 and October 2020 were identified and divided into 3 study groups (i.e., control, patients with known opioid use disorder, and patients identified as cannabis users). Differences in the incidence of complications within 30 days of the index procedure and pseudarthrosis rates at 18 months postindex procedure were assessed among study groups using a multivariate logistic regression.
    UNASSIGNED: Of 12.4% study population used cannabis and 38.8% had a known opioid use disorder. Results indicated increased odds of experiencing a VTE, hypoxia, myocardial infarction, and arrhythmia for both opioid and cannabis users compared to controls; however, when controlling for tobacco use there were no increased odds of complications within the cannabis group. The pseudarthrosis rate was greater in cannabis users (2.4%) than in controls (1.1%).
    UNASSIGNED: The pseudarthrosis rate was significantly greater in patients using cannabis and opioids compared to the control group. However, when controlling for tobacco use, results suggested a possible negative synergistic between cannabis use and concomitant tobacco use that may influence bone fusion.
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  • 文章类型: Journal Article
    原发性椎间盘切除术后椎间盘突出症的公开发生率约为6%,但患者在接受椎间盘翻修术后的最终再手术结果尚不清楚.此外,初次/翻修椎间盘切除术后,术后椎间盘翻修术(SRD)与术后腰椎融合术(SLF)结果的差异仍未得到充分研究.
    分别确定初次/翻修椎间盘切除术后8年SRD/SLF发生率和直至SRD/SLF的时间。
    回顾性队列研究。
    接受初次或修正椎间盘切除术的患者,2010年至2019年PearlDiver患者记录数据库中的记录。
    后续手术类型和后续手术时间。
    从2010年到PearlDiver患者记录数据库中的19个保险数据集,使用ICD9/10和CPT程序代码,根据“索引”程序(初次或修正椎间盘切除术)的性质,将患者分为初次或修正椎间盘切除术队列。收集术前人口统计学数据。在PearlDiverMariner数据库中前瞻性地收集了诸如后续手术类型(融合或椎间盘切除术)和后续手术时间等结果指标。使用BellWeather统计软件进行统计分析。对每个队列进行SLF/SRD时间的Kaplan-Meier生存分析,和对数秩检验用于比较队列之间的SLF/SRD率。
    共确认20,147例患者(17,849例原发性椎间盘切除术,2,298修正椎间盘切除术)。8年SRD发生率(修订队列中6.1%,初级队列中的4.8%,p<.01)和SLF(修订队列中的10.4%,初级队列中的6.2%,p<.01)在翻修后比原发性椎间盘切除术后更高。与原发性椎间盘切除术相比,翻修后的SLF时间较短(709与886天,p<.01)。在初次和修正椎间盘切除术后,8年SLF率(修订队列中为10.4%,初级队列中的6.2%,p<.01)大于SRD(修订队列中的6.1%,初级队列中的4.8%,p<.01)。
    与原发性椎间盘切除术相比,椎间盘翻修术的SLF发生率较高(10.4%vs.6.2%),和更快的SLF时间(2.4与1.9年),随访8年。
    Published rates for disc reherniation following primary discectomy are around 6%, but the ultimate reoperation outcomes in patients after receiving revision discectomy are not well understood. Additionally, any disparity in the outcomes of subsequent revision discectomy (SRD) versus subsequent lumbar fusion (SLF) following primary/revision discectomy remains poorly studied.
    To determine the 8-year SRD/SLF rates and time until SRD/SLF after primary/revision discectomy respectively.
    Retrospective cohort study.
    Patients undergoing primary or revision discectomy, with records in the PearlDiver Patient Records Database from the years 2010 to 2019.
    Subsequent surgery type and time to subsequent surgery.
    Patients were grouped into primary or revision discectomy cohorts based off of the nature of \"index\" procedure (primary or revision discectomy) using ICD9/10 and CPT procedure codes from 2010 to 19 insurance data sets in the PearlDiver Patient Records Database. Preoperative demographic data was collected. Outcome measures such as subsequent surgery type (fusion or discectomy) and time to subsequent surgery were collected prospectively in PearlDiver Mariner database. Statistical analysis was performed using BellWeather statistical software. A Kaplan-Meier survival analysis of time to SLF/SRD was performed on each cohort, and log-rank test was used to compare the rates of SLF/SRD between cohorts.
    A total of 20,147 patients were identified (17,849 primary discectomy, 2,298 revision discectomy). The 8-year rates of SRD (6.1% in revision cohort, 4.8% in primary cohort, p<.01) and SLF (10.4% in revision cohort, 6.2% in primary cohort, p<.01) were higher after revision versus primary discectomy. Time to SLF was shorter after revision versus primary discectomy (709 vs. 886 days, p<.01). After both primary and revision discectomy, the 8-year rate of SLF (10.4% in revision cohort, 6.2% in primary cohort, p<.01) is greater than SRD (6.1% in revision cohort, 4.8% in primary cohort, p<.01).
    Compared to primary discectomy, revision discectomy has higher rates of SLF (10.4% vs. 6.2%), and faster time to SLF (2.4 vs. 1.9 years) at 8-year follow up.
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  • 文章类型: Journal Article
    Objective: Anterior cruciate ligament (ACL) tears are more prevalent in females than males. One of the factors responsible for this may be the variation in levels of estrogen and progesterone. The purpose of this study was to determine the potentially protective effects of oral contraceptive pills (OCPs) on ACL tears.Methods: The PearlDiver database (www.pearldiverinc.com, Fort Wayne, IN) was queried for all OCP users amongst females aged 15-49. Female experiencing an ACL tear and undergoing surgery (CPT 29,888) were compared to a control group of females undergoing surgery for an ACL tear, but not on OCPs. Chi-squared testing was used to assess for significant differences in the rate of ACL reconstruction for the OCP and non-OCP users, according to age groups broken down into age intervals of 5 years.Results: There were a total 82,874 patients in both the OCP and non-OCP groups. There was a total of 569 (0.69%) ACL reconstructions in the non-OCP group and 465 (0.56%) in the OCP group (p < 0.001). In the non-OCP group, patients aged 15-19 accounted for 29.35% of all ACL reconstructions, whereas, in the OCP group, this same age group only accounted for 13.33%. Among all age groups, the odds ratios for experiencing an ACL reconstruction while on OCP was 0.82 (χ2 = 0.001, 95% CI 0.72-0.92) compared to not using OCP. This protective effect was driven primarily by the 15-19 age group (odds ratio 0.37 (χ2 < 0.001, 95% CI 0.27-0.50)). The number need to treat for OCP usage in the 15-19 age group was six patients.Conclusions: OCPs have a protective effect on ACL tear, especially in the 15-19 age group, which exhibited a 63% reduction in the rate of tear. Consideration should be given to prescribing OCPs to younger athletes, after careful assessment of the risks of these commonly prescribed medications.Level of evidence: III.
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  • 文章类型: Journal Article
    OBJECTIVE: The aim of our study was to investigate the trends and incidence of vertebral augmentation procedures (VAPs) in treating osteoporotic vertebral compression fractures.
    RESULTS: In total, 118,074 patients were analyzed. The overall incidence of VAPs was 15.2%. The incidence of VAPs was significantly higher in those 75-79 years old (20.4%), significantly higher in females than males (15.6% versus 14.9%), and most commonly performed in the South (17.7%).
    CONCLUSIONS: There was a decline in the frequency of these procedures since 2008, but physicians are still performing these procedures, albeit at a much lower frequency than before 2009.
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